Oocyte-specific genes affect folliculogenesis, fertilization, and early development.
Oocyte-specific genes affect folliculogenesis, fertilization, and early development.
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DOI：
10.1055/s-2007-980218
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发表时间：
2007-07
影响因子：
2.7
通讯作者：
P. Zheng;J. Dean
中科院分区：
文献类型：
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作者：
P. Zheng;J. Dean
虽然生殖细胞和体细胞追求的细胞自主遗传程序至关重要，但两种细胞类型之间的密切相互作用对于女性性腺的正常发育也是必不可少的。近年来的研究表明，卵母细胞在卵泡发育过程中体细胞生长和分化的协调中起着积极的作用，并影响受精和早期发育的成功结果。小鼠转基因在确定生殖细胞特异性基因及其在卵泡发生中的作用（例如，DAZLA、FIGLA、NOBOX、SOHLH1、YBX 2、CPEB 1、GDF 9）、受精（例如，ZP1、ZP2、ZP3）和植入前胚胎发育（例如，NPM2、ZAR 1、NALP 5、DPPA 3）。继续鉴定新的卵母细胞特异性基因及其功能的注释将为调节卵巢发育的遗传途径提供更多的见解。从小鼠模型中获得的知识无疑将有助于理解人类生物学和治疗生殖失败。
Although cell-autonomous genetic programs pursued by germ and somatic cells are of critical import, intimate interplays between the two cell types are also essential for normal development of the female gonad. Recent studies demonstrate that oocytes play active roles in coordinating the growth and differentiation of somatic cells during folliculogenesis and affect successful outcomes at fertilization and early development. Mouse transgenesis has been particularly useful in defining germ-cell specific genes and their roles in folliculogenesis (e.g., DAZLA, FIGLA, NOBOX, SOHLH1, YBX2, CPEB1, GDF9), fertilization (e.g., ZP1, ZP2, ZP3), and preimplantation embryonic development (e.g., NPM2, ZAR1, NALP5, DPPA3). Continued identification of novel oocyte-specific genes and the annotation of their functions will provide additional insight into the genetic pathways regulating ovarian development. The knowledge gained from mouse models will no doubt benefit the understanding of human biology and treatment of reproductive failure.