Differential Effect of Capsaicin Treatment on Pain-Related Behaviors After Plantar Incision
Differential Effect of Capsaicin Treatment on Pain-Related Behaviors After Plantar Incision
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DOI：
10.1016/j.jpain.2009.01.003
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发表时间：
2009-06-01
期刊：
影响因子：
4
通讯作者：
Brennan, Timothy J.
中科院分区：
文献类型：
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作者：
Hamalainen, Minna M.;Subieta, Alberto;Brennan, Timothy J.
我们评估了在足底切口前给予辣椒素稀释溶液浸润对3种疼痛相关行为的影响：疼痛防御、热退缩潜伏期和机械退缩阈值。还研究了辣椒素的神经周围应用，并对伤口的外观进行了评价。0.025%和0.10%的辣椒素稀释溶液在切开前1天渗入足底区域。在另一组大鼠中，将神经周辣椒素（1%）施加于支配大鼠后爪的足底面的神经。然后在足底切口之前和之后以及之后每天测试大鼠的疼痛相关行为。对伤口外观进行分级，并进行组织病理学评价。辣椒素浸润减少足底切口后的守卫疼痛和热痛觉过敏，对机械反应的影响很小。神经周辣椒素应用产生了类似的结果。辣椒素浸润和神经膜辣椒素应用均损害伤口贴壁。组织学评价也证实了辣椒素浸润后伤口贴壁受损。总之，辣椒素的稀释溶液对足底切口后疼痛相关行为有不同的影响。基于辣椒素通过渗透和神经周围注射产生的抗伤害性，对伤口外观的影响可能与其对疼痛行为的抑制作用有关，并不一定是局部效应的drug.Perspective：这项研究表明，辣椒素渗透足底切口前产生的镇痛效果，依赖于刺激方式测试。在评价术后疼痛的新治疗方法时，使用单一刺激方式的研究可能会因未检查各种刺激而忽略镇痛效果。(C)2009年美国疼痛协会
We evaluated the effect of infiltration of dilute solutions of capsaicin, administered before plantar incision, on 3 pain-related behaviors: guarding pain, heat-withdrawal latency, and mechanical withdrawal threshold. Perineural application of capsaicin was also studied and the appearance of the wound was also evaluated. Dilute solutions of capsaicin .025% and .10% were infiltrated in the plantar region 1 day before incision. In another group of rats, perineural capsaicin (1%) was applied to the nerves innervating the plantar aspect of the rat hindpaw. Rats were then tested for pain-related behaviors before and after plantar incision and then daily thereafter. Wound appearance was graded and histopathology was evaluated. Infiltration with capsaicin reduced guarding pain and heat hyperalgesia after plantar incision; there were minimal effects on mechanical responses. Perineural-capsaicin application produced a similar result. Both capsaicin infiltration and perineural-capsaicin application impaired wound apposition. Histologic evaluation also confirmed impaired wound apposition after capsaicin infiltration. In conclusion, dilute solutions of capsaicin have differential effects on pain-related behaviors after plantar incision. Based on the antinociception produced by capsaicin both via infiltration and perineural injection, the effect on wound appearance was likely related to its inhibitory effects on pain behaviors and was not necessarily a local effect of the drug.Perspective: This study demonstrated that capsaicin infiltration before plantar incision produced an analgesic effect that depended upon the stimulus modality tested. When evaluating novel treatments for postoperative pain, studies using a single stimulus modality may overlook an analgesic effect by not examining a variety of stimuli. (C) 2009 by the American Pain Society