YAP and TAZ: a nexus for Hippo signaling and beyond.
YAP and TAZ: a nexus for Hippo signaling and beyond.
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DOI：
10.1016/j.tcb.2015.05.002
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发表时间：
2015-09
影响因子：
19
通讯作者：
Guan KL
中科院分区：
文献类型：
--
作者：
Hansen CG;Moroishi T;Guan KL
Hippo通路是细胞增殖、分化和组织稳态的有效调节剂。本文综述了Hippo信号通路的调控机制，并讨论了Hippo信号通路的主要调节因子--Yes相关蛋白（雅普）/转录辅激活因子与PDZ结合域（TAZ）在干细胞生物学和组织再生中的作用。我们强调了它们在细胞核和细胞质中的活性，并讨论了它们作为其他几种主要信号通路（如Wnt、G蛋白偶联受体（GPCR）、表皮生长因子（EGF）、BMP/转化生长因子β（TGFβ）和Notch通路）的信号联系和整合剂的作用。
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue regeneration. We highlight their activities in both the nucleus and the cytoplasm and discuss their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), BMP/transforming growth factor beta (TGFβ), and Notch pathways.