Comparative biology of Ca2+-dependent exocytosis:: implications of kinetic diversity for secretory function
Comparative biology of Ca2+-dependent exocytosis:: implications of kinetic diversity for secretory function
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DOI：
10.1016/s0166-2236(98)01293-4
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发表时间：
1999-02-01
影响因子：
15.9
通讯作者：
Kasai, H
中科院分区：
文献类型：
--
作者：
Kasai, H
笼状Ca2+化合物在Ca2+依赖性胞吐作用研究中的应用已经开始揭示这一重要过程中的动力学中间体。胞吐的时间过程在不同的细胞和囊泡类型之间差异很大，甚至在响应相同幅度的Ca2+“跳跃”时也是如此。Ca2+结合到假定的Ca2+传感器的胞吐动力学也有所不同。理论分析表明，胞吐和Ca2+结合反应的动力学多样性对胞吐发生的概率有不同的决定作用。有人提出，这两种反应都针对特定细胞类型的分泌功能进行了优化，胞外反应除了囊泡与质膜融合外，还包括囊泡易位。
The application of caged-Ca2+ compounds to the study of Ca2+-dependent exocytosis has begun to reveal kinetic intermediates in this important process. The time course of exocytosis varies greatly among different cell and vesicle types, even in response to Ca2+ 'jumps' of identical amplitude. The kinetics of the binding of Ca2+ to the putative Ca2+ sensor for exocytosis also vary. Theoretical analysis reveals that the kinetic: diversity of exocytotic and Ca2+-binding reactions has distinct roles in determining the probability of exocytosis occurring. it is proposed that both of these reactions are optimized for the secretory function of specific cell types and that the exocytotic reaction includes vesicle translocation in addition to the fusion of vesicles with the plasma membrane.