Quality of life among long-term non-Hodgkin lymphoma survivors - A population-based study
Quality of life among long-term non-Hodgkin lymphoma survivors - A population-based study
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DOI：
10.1002/cncr.22581
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发表时间：
2007-04-15
期刊：
影响因子：
6.2
通讯作者：
van de Poll-Franse, Lonneke V.
中科院分区：
文献类型：
--
作者：
Mols, Floortje;Aaronson, Neil K.;van de Poll-Franse, Lonneke V.
背景。这项基于人群的研究的目的是记录非霍奇金淋巴瘤的长期影响（诊断后 5-15 年）及其治疗对健康相关生活质量 (HRQL) 和社会问题的影响。方法。以人群为基础的埃因霍温癌症登记处用于选择1989年至1998年间所有被诊断为非霍奇金淋巴瘤的患者。邀请360名患者完成36项简短健康调查（SF-36）和生活质量-癌症幸存者调查问卷，294名患者（82%）做出了回应。 结果。接受化疗的患者报告的心理和社会福祉以及健康相关的生活质量（HRQL）明显低于未接受化疗的患者。放疗和观察等待与 HRQL 结果没有显着相关性。 10 至 15 年前被诊断的患者比 5 至 9 年前被诊断的患者表现出更好的社会幸福感。与一般人群中年龄匹配的标准样本相比，患者的总体健康状况明显较差，活力较低，但身体疼痛较少。据报告，实际问题涉及工作（41%）、获得医疗保险（6%）和人寿保险（15%）以及获得住房抵押贷款（22%）。结论。诊断后 5 至 15 年，非霍奇金淋巴瘤幸存者的总体健康认知和活力水平仍然显着低于一般人群的同龄人。此外，幸存者还面临工作和财务方面的实际问题，在康复期间值得额外关注。
BACKGROUND. The objective of this population-based study was to document the long-term effects (5-15 years postdiagnosis) of non-Hodgkin lymphoma and its treatment on health-related quality of life (HRQL) and social problems.METHODS. The population-based Eindhoven Cancer Registry was used to select all patients who were diagnosed with non-Hodgkin lymphoma from 1989 to 1998. Three hundred sixty patients were invited to complete the 36-item Short Form Health Survey (SF-36) and the Quality of Life-Cancer Survivors questionnaire, and 294 patients (82%) responded.RESULTS. Patients who had received chemotherapy reported significantly worse psychological and social well-being and health-related quality of life (HRQL) than patients who had not received chemotherapy. Radiotherapy and watchful waiting were not associated significantly with HRQL outcomes. Patients who were diagnosed from 10 to 15 years earlier reported better social well-being than patients who were diagnosed from 5 to 9 years earlier. Compared with an age-matched, normative sample from the general population, patients reported significantly worse general health and less vitality, but they reported less bodily pain. Practical problems were reported with work (41%), obtaining health care insurance (6%) and life insurance (15%), and obtaining a home mortgage (22%).CONCLUSIONS. From 5 to 15 years after diagnosis, the general health perceptions and vitality levels of non-Hodgkin lymphoma survivors remained significantly lower than those of their peers in the of general population. In addition, survivors faced practical problems with work and finances that deserve additional attention during the period of rehabilitation.