C-reactive protein and substance use disorders in adolescence and early adulthood: A prospective analysis
C-reactive protein and substance use disorders in adolescence and early adulthood: A prospective analysis
复制标题
DOI：
10.1016/j.drugalcdep.2013.08.027
复制
发表时间：
2013-12-01
影响因子：
4.2
通讯作者：
Angold, Adrian
中科院分区：
文献类型：
--
作者：
Costello, E. Jane;Copeland, William E.;Angold, Adrian
背景资料：慢性疾病（包括一些精神疾病）的成年人存在免疫功能失调和炎症标志物升高，但药物滥用情况下的炎症证据相互矛盾。目的：在青少年和年轻人的纵向人群样本中，检测C反应蛋白（CRP）与酒精、尼古丁和大麻使用和滥用之间的并发和预测关系，方法：数据来自前瞻性的人口为基础的大烟山研究（N = 1420），包括儿童在社区评估的年龄在9- 16，19和21。结构化访谈被用来评估药物滥用症状和DSM-IV物质使用障碍。在每次评估和分析CRP。结果：CRP水平较高的尼古丁，酒精和大麻的使用和尼古丁依赖的存在。在前瞻性分析中，一旦将协变量纳入模型，较高的CRP水平可预测大麻使用和尼古丁依赖，尼古丁使用可预测较高的CRP水平。显着的协变量是年龄，种族（美国印第安人），和obesity.Conclusions：CRP和药物滥用的相互关系有影响，后来的健康风险与早期药物和酒精的使用和滥用。(C)由Elsevier爱尔兰有限公司出版。
Background: Dysregulated immune function and elevated inflammation markers are seen in adults with chronic diseases, including some psychiatric disorders, but evidence on inflammation in the case of drug abuse is conflicting.Objective: To test the concurrent and predictive relations between C-reactive protein (CRP) and use and abuse of alcohol, nicotine and cannabis in a longitudinal, population sample of adolescents and young adults, at the period of highest increase in drug use.Methods: Data from the prospective population-based Great Smoky Mountains Study (N = 1420) were used, covering children in the community assessed at ages 9-16,19, and 21. Structured interviews were used to assess substance abuse symptoms and DSM-IV substance use disorders. Bloodspots were collected at each assessment and assayed for CRP.Results: CRP levels were higher in the presence of nicotine, alcohol, and cannabis use and nicotine dependence. In prospective analyses, higher CRP levels predicted cannabis use and nicotine dependence, and nicotine use predicted higher CRP levels, once covariates were included in the models. Significant covariates were age, race (American Indian), and obesity.Conclusions: The inter-relationship of CRP and substance abuse has implications for the later health risks associated with early drug and alcohol use and abuse. (C) 2013 Published by Elsevier Ireland Ltd.