Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice
Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice
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DOI：
10.1016/j.bbi.2004.09.004
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发表时间：
2005-05-01
影响因子：
15.1
通讯作者：
Marucha, PT
中科院分区：
文献类型：
--
作者：
Horan, MP;Quan, N;Marucha, PT
先前的研究表明，心理压力会使伤口愈合延迟25%以上。促炎细胞因子的基因表达和上皮的成熟也受到应激的损害（Mercado等人）。伤口收缩有助于伤口闭合的速度（Hunt和Hopf）。在目前的研究中，伤口收缩减少>45%（p
Previous research has shown that psychological stress delays wound closure by >25%. Gene expression of pro-inflammatory cytokines and the maturation of the epithelium were also impaired by stress (Mercado et al.). Wound contraction contributes to the speed of wound closure (Hunt and Hopf). In the current study, wound contraction was decreased by >45% (p