Bone allografts pretreated with a bisphosphonate are not resorbed
Bone allografts pretreated with a bisphosphonate are not resorbed
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DOI：
10.1080/000164702317281350
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Åstrand, J
中科院分区：
文献类型：
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作者：
Aspenberg, P;Åstrand, J
双膦酸盐与骨表面结合，当破骨细胞开始吸收骨头时，它们就会失去活性。因此，在植入前将骨移植物浸泡在双膦酸盐溶液中可以防止骨移植物被吸收。我们植入冷冻松质瘤；异体骨;10只大鼠入双侧骨腔6周。每对移植物中的一个在阿仑膦酸钠溶液（1mg /mL）中浸泡10分钟，然后在生理盐水中冲洗。对照组接受同样的生理盐水治疗。用组织形态计量学对结果进行评价。对照移植物几乎完全被吸收，但阿仑膦酸钠处理的移植物似乎完好无损。在处理过的标本中，骨长入边界后面的三分之二的空间由移植物或宿主骨组成，但在对照组中，只有五分之一。植入前用二膦酸盐进行局部移植物治疗似乎是无风险的，并且可以防止患者因吸收而导致的机械移植物失败。
Bisphosphonates bind to bone surfaces and inactivate osteoclasts when they start to resorb the bone. Therefore, immersion of a bone graft in a bisphosphonate solution before implantation may protect it from resorption.We implanted frozen cancellous; bone allografts; into bilateral bone chambers for 6 weeks in 10 rats. One graft in each pair had been immersed in an alendronate solution (1 mg/mL) for 10 minutes, and then rinsed in saline. Controls underwent the same treatment with saline only. Results were evaluated with histomorphometry. Control grafts were almost entirely resorbed, but alendronate-treated grafts seemed intact. In the treated specimens, two thirds of the space behind the bone ingrowth frontier consisted of graft or host bone, but in the controls, only one fifth. Local graft treatment with a bisphosphonate before insertion seems to be risk-free, and may prevent mechanical graft failure due to resorption in patients.