Co-occurrence of monoclonal gammopathy and myelodysplasia: a retrospective study of fourteen cases.
Co-occurrence of monoclonal gammopathy and myelodysplasia: a retrospective study of fourteen cases.
复制标题
单克隆丙种球蛋白病和骨髓增生异常的共存：十四例病例的回顾性研究。
DOI：
10.1007/s12185-014-1570-6
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发表时间：
2014
期刊：
影响因子：
2.1
通讯作者：
Kawabata H.
中科院分区：
文献类型：
--
作者：
1.Yoshida Y;Oguma S;Ohno H;Nakabo Y;Katsurada T;Kawahara M;Kawabata H.
我们报告了一系列的14例骨髓增生异常综合征（MDS）伴随单克隆丙种球蛋白病无关的治疗。其中12例为单克隆丙种球蛋白病（MGUS），2例为郁积型多发性骨髓瘤。这些病例占我们机构14年期间（2000年1月至2013年12月）所有MDS病例的10.2%。经χ 2检验，MDS患者MGUS发生率显著高于同期对照组。在大多数情况下，没有既往化疗和MDS和MGUS的同时出现提示这两种疾病的真正共同发生。MGUS在MDS的所有WHO亚型中均有发现，具有广泛的危险因素。而12例MDS合并MGUS患者中有11例核型风险相对较低。此外，血清M蛋白水平在4例MGUS中基本保持不变，进行了系列测定。这些结果表明MGUS可能不影响MDS的预后。
We report a series of 14 patients with myelodysplastic syndrome (MDS) accompanied by a monoclonal gammopathy unrelated to therapy. Twelve of these had monoclonal gammopathy of undermined significance (MGUS) and two had smoldering multiple myeloma. These cases represent 10.2 % of all MDS cases seen at our institution over a 14-year period (January 2000 to December 2013). The incidence of MGUS was determined to be significantly higher in MDS than in age-matched concurrent controls byχ2test. Absence of prior chemotherapy and simultaneous presentation of MDS and MGUS in most cases suggest true co-occurrence of the two disorders. MGUS was found in all WHO subtypes of MDS with a wide range of risk factors. However, 11 out of the 12 MDS cases accompanied with MGUS had relatively low karyotypic risks. In addition, serum M protein levels remained largely unchanged in 4 cases of MGUS for which serial determinations were performed. These findings indicate that MGUS may not affect the prognosis of MDS.