IS VASOSPASM RELATED TO PLATELET DEPOSITION - RELATIONSHIP IN A PORCINE PREPARATION OF ARTERIAL INJURY INVIVO
IS VASOSPASM RELATED TO PLATELET DEPOSITION - RELATIONSHIP IN A PORCINE PREPARATION OF ARTERIAL INJURY INVIVO
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DOI：
10.1161/01.cir.75.1.243
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发表时间：
1987-01-01
期刊：
影响因子：
37.8
通讯作者：
FUSTER, V
中科院分区：
文献类型：
--
作者：
LAM, JYT;CHESEBRO, JH;FUSTER, V
虽然聚集的血小板在体外可以释放有效的血管活性物质，但血小板在体内介导自然发生或诱发的痉挛中的重要性尚不清楚。为了研究血小板在血管成形术诱导的动脉损伤后动脉痉挛中的可能作用，在42只肝素化的正常猪中研究了扩张动脉段的定量血小板沉积和颈总动脉血管成形术期间产生的血管收缩程度（扩张段近端和远端的平均直径狭窄百分比），这些猪在血管成形术后立即处死。在扩张前和扩张后拍摄颈动脉血管造影片以评估血管收缩。当血小板沉积（× 1000）时，血管收缩更大（40%对19%，p <0.002）。106/cm 2）超过10，并且体内血管收缩的严重程度与24只未处理的猪中血小板沉积的程度具有密切的正指数相关性（r = 0.77，p <0.001）。严重心房壁损伤的血小板沉积和血管收缩比轻度损伤的更大（分别为58.8 vs. 6.9，p <0.0001; 37% vs. 21%，p <0.001）。在18只猪严重损伤后，与对照组相比，用1 mg/kg/天阿司匹林预处理，血小板沉积减少（从58.8降至19.6，p <0.02），血管收缩减少（从37%降至21%，p <0.003）。轻度损伤后，血小板沉积和血管收缩轻微，阿司匹林无变化。因此，局部血管收缩受血小板沉积程度的影响。这是第一次报道在体内定量血小板沉积和局部血管收缩之间的相关性，在动脉损伤的网站和减少血管收缩的血小板抑制剂治疗。
Although aggregating platelets can release potent vasoactive substances in vitro, the importance of platelets in mediating naturally occurring or provoked spasm in vivo is not clear. To investigate the possible role of platelets in arteiral spasm following arterial injury induced by angioplasty, quantitative platelet deposition of the dilated arterial segment and the degree of vasoconstriction (average percent diameter narrowing just proximal and distal to the dilated segment) produced during angioplasty of the common carotid arteries were studied in 42 heparinized normal pigs that were killed immediately after the angioplasty procedure. Angiographic films of the carotid arteries were taken before and after the dilatation to assess the vasoconstriction. Vasoconstriction was greater (40% vs 19%, p < .002) when platelet deposition (.times. 106/cm2) was in excess of 10, and the severity of vasoconstriction in vivo had a close positive exponential correlation (r = .77, p < .001) with the extent of platelet deposition in 24 untreated pigs. Platelet deposition and vasoconstriction were greater with severe atrial wall injury than with mild injury (58.8 versus 6.9, p < .0001; 37% vs. 21%, p < .001, respectively). After severe injury in 18 pigs pretreated with 1 mg/kg/day aspirin, platelet deposition decreased (from 58.8 to 19.6, p < .02) and vasocontriction decreased (from 37% to 21%, p < .003) relative to control. After mild injury, platelet deposition and vasoconstriction were mild and unchanged by aspirin. Thus, local vasoconstriction is influenced by the degree of platelet deposition. This is the first reported correlation in vivo between quantitative platelet deposition and localized vasoconstriction at the site of the arterial injury and the reduction of vasoconstriction by platelet inhibitor therapy.