Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution
Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution
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DOI：
10.1016/j.bbrc.2008.08.047
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发表时间：
2008-10-31
影响因子：
3.1
通讯作者：
Baker, Michael E.
中科院分区：
文献类型：
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作者：
Baker, Michael E.
虽然，顾名思义，雌激素受体[ER]和雌激素相关受体[ERS]是相关的转录因子，但它们之间的进化关系并不完全清楚。为了阐明ERS和ERS的起源和进化，我们在已知最简单的动物Trichoplax的最近测序的基因组中以及三种轮虫的基因组中搜索了它们的同源基因：环节动物Capitella，环节动物Helobdella robusta，水蚤Helobdella robusta和蜗牛Lottia Gigantea。BLAST搜索发现Trichoplax有错误，但没有急诊室。BLAST搜索还在卡皮特拉和洛蒂亚的所有三种Lophotrochozoans和类似无脊椎动物的ER中发现了错误，但在Helobdella中没有。出人意料的是，我们发现Capitella ER序列最接近ER beta，而不像其他无脊椎动物ER序列最接近ERα。我们的数据库搜索和系统发育分析表明，无脊椎动物的内质网在轮虫中进化，类固醇结合的内质网在后口动物中进化。(C)2008 Elsevier Inc.保留所有权利。
Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. To elucidate the origins and evolution of ERs and ERRs, we searched for their orthologs in the recently sequenced genome of Trichoplax, the simplest known animal, and in the genomes of three lophotrochozoans: Capitella, an annelid worm, Helobdella robusta, a leech, and Lottia gigantea, a snail. BLAST searches found an ERR in Trichoplax, but no ER. BLAST searches also found ERRs in all three lophotrochozoans and invertebrate-like ERs in Capitella and Lottia, but not in Helobdella. Unexpectedly we find that the Capitella ER sequence is closest to ER beta, unlike the other invertebrate ER sequences, which are closest to ER alpha. Our database searches and phylogenetic analysis indicate that invertebrate ERs evolved in a lophotrochozoan and steroid-binding ERs evolved in a deuterostome. (c) 2008 Elsevier Inc. All rights reserved.