EPITHELIAL-CELL SURFACES INDUCE SALMONELLA PROTEINS REQUIRED FOR BACTERIAL ADHERENCE AND INVASION
EPITHELIAL-CELL SURFACES INDUCE SALMONELLA PROTEINS REQUIRED FOR BACTERIAL ADHERENCE AND INVASION
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DOI：
10.1126/science.2919285
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发表时间：
1989-02-17
期刊：
影响因子：
56.9
通讯作者：
FALKOW, S
中科院分区：
文献类型：
--
作者：
FINLAY, BB;HEFFRON, F;FALKOW, S
沙门氏菌能够进入(入侵)真核细胞并在其中繁殖。霍乱沙门氏菌和鼠伤寒沙门氏菌对上皮细胞的稳定黏附和侵袭需要重新合成几种新的细菌蛋白。这一可诱导的事件似乎是一个协调调节的系统，依赖于上皮细胞表面存在的胰酶和神经氨酸酶敏感结构。霍乱沙门氏菌和鼠伤寒沙门氏菌的突变体不能合成这些蛋白，也不能稳定地附着或入侵真核细胞。两个这样的鼠伤寒沙门氏菌突变体在小鼠中是无毒的，这表明这些蛋白是沙门氏菌毒力所必需的。
Salmonella bacteria are capable of entering (invading) and multiplying within eukaryotic cells. Stable adherence to and invasion of epithelial cells by S. choleraesuis and S. typhimurium were found to require de novo synthesis of several new bacterial proteins. This inducible event appears to be a coordinately regulated system dependent on trypsin- and neuraminidase-sensitive structures present on the epithelial cell surface. Mutants of S. choleraesuis and S. typhimurium were unable to synthesize these proteins and did not stably adhere to nor invade eukaryotic cells. Two such S. typhimurium mutants were avirulent in mice, an indication that these proteins are required for Salmonella virulence.