Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model.
Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model.
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DOI：
10.1016/j.biomaterials.2014.07.065
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发表时间：
2014-12
期刊：
影响因子：
14
通讯作者：
Boyan, Barbara D.
中科院分区：
文献类型：
--
作者：
Hermann, Christopher D.;Wilson, David S.;Lawrence, Kelsey A.;Ning, Xinghai;Olivares-Navarrete, Rene;Williams, Joseph K.;Guldberg, Robert E.;Murthy, Niren;Schwartz, Zvi;Boyan, Barbara D.
Craniosynostosis is the premature fusion of cranial sutures, which can result in progressive cranial deformations, increased intracranial pressure, and restricted brain growth. Most cases of craniosynostosis require surgical reconstruction of the cranial vault with the goal of increasing the intracranial volume and correcting the craniofacial deformities. However, patients often experience rapid post-operative bone re-growth, known as re-synostosis, which necessitates additional surgical intervention. Bone morphogenic protein (BMP) inhibitors have tremendous potential to treat re-synostosis, but the realization of a clinically viable inhibitor-based therapeutic requires the development of a delivery vehicle that can localize the release to the site of administration. Here, we present an in situ rapidly crosslinking injectable hydrogel that has the properties necessary to encapsulate co-administered proteins and demonstrate that the delivery of rmGremlin1 via our hydrogel system delays bone re-growth in a weanling mouse model of re-synostosis. Our hydrogel is composed of two mutually reactive poly(ethylene glycol) macromolecules, which when mixed crosslink via a bio-orthogonal Cu free click reaction. Hydrogels containing Gremlin caused a dose-dependent inhibition of bone regrowth. In addition to craniofacial applications, our injectable click hydrogel has the potential to provide customizable protein, small molecule, and cell delivery to any site accessible via needle or catheter.
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DOI：
10.1597/07-095.1
发表时间：
2008-11-01
期刊：
CLEFT PALATE-CRANIOFACIAL JOURNAL
影响因子：
--
作者：
Frazier, Brenda C.;Mooney, Mark P.;Richtsmeier, Joan T.
通讯作者：
Richtsmeier, Joan T.
影响因子：
3.8
作者：
Hermann, Christopher D.;Richards, Megan A.;Boyan, Barbara D.
通讯作者：
Boyan, Barbara D.
影响因子：
3.6
作者：
Cooper, Gregory M.;Usas, Arvydas;Huard, Johnny
通讯作者：
Huard, Johnny
影响因子：
3.6
作者：
Gosain, AK;McCarthy, JG;Wisoff, JH
通讯作者：
Wisoff, JH
影响因子：
6.2
作者：
Cooper, Gregory M.;Curry, Chris;Mooney, Mark P.
通讯作者：
Mooney, Mark P.