Evidence for a change in neurotransmitter affecting oesophageal motility in Parkinson's disease.
Evidence for a change in neurotransmitter affecting oesophageal motility in Parkinson's disease.
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影响帕金森病食管运动的神经递质变化的证据。
DOI：
10.1136/jnnp.41.8.709
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
A. Dellipiani
中科院分区：
文献类型：
--
作者：
M. Bramble;J. Cunliffe;A. Dellipiani
在一项针对 20 名帕金森病患者的食管运动的研究中，与对照组相比，静脉注射阿托品对吞咽反应的协调产生了明显的破坏。这表明胆碱能机制比多巴胺能机制在帕金森病患者吞咽控制中更重要。尽管在严重受影响的患者中发现了提示前者的微小变化，但没有发现外周多巴胺耗竭或自主神经病变确实的证据。
In a study of oesophageal motility in 20 patients with Parkinson's disease, intravenous atropine produced marked disruption of co-ordination in response to swallows, when compared with control subjects. This suggests that cholinergic rather than dopaminergic mechanisms are more important in the control of swallowing in patients with Parkinsonism. No conclusive evidence of peripheral dopamine depletion or autonomic neuropathy was found, although minor changes suggestive of the former were found in severely affected patients.