Early responses of testicular interstitial cells to stimulation by interstitial-cell-stimulating hormone.
Early responses of testicular interstitial cells to stimulation by interstitial-cell-stimulating hormone.
复制标题
睾丸间质细胞对间质细胞刺激激素刺激的早期反应。
DOI：
10.1002/aja.1001340208
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
E. Massa
中科院分区：
文献类型：
--
作者：
A. Aoki;E. Massa
描述了处于不同实验条件下的小鼠睾丸间质细胞的精细结构。用垂体促性腺活性的选择性抑制剂 methallibure（I.C.I. 33,828；1-α-甲基烯丙基硫代氨基甲酰基-2-甲基硫代氨基甲酰肼）治疗后，间质细胞获得静止外观，其特征为：(1) 无颗粒内质网与其他细胞质细胞器和内含物的分离加剧，(2) 脂质储存增加水滴。单次注射间质细胞刺激激素（ICSH 或 LH）会引起细胞内含物和细胞器的超微结构和分布发生显着变化，这似乎与分泌活性增强有关。细胞表面显示出细胞质突起的显着发育，这些突起与相邻细胞的类似突起相互交叉。细胞间隙形成界面通道系统，提供间质细胞表面与血管和曲细精管肌样层的直接连接。促性腺刺激导致游离核糖体数量增加以及高尔基复合体和粗面内质网扩张。脂滴明显减少并形成脂褐素颗粒。
The fine structure of testicular interstitial cells from mice submitted to different experimental conditions is described. Following treatment with methallibure (I.C.I. 33,828; 1-α-methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine), a selective inhibitor of hypophyseal gonadotropic activity, interstitial cells acquire a quiescent appearance characterized by: (1) accentuated segregation of agranular endoplasmic reticulum from other cytoplasmic organelles and inclusions, (2) increased depots of lipid droplets. A single injection of interstitial-cell-stimulating hormone (ICSH or LH) induces prominent changes in the ultrastructure and distribution of cell inclusions and organelles that are seemingly related to augmented secretory activity. The cell surface shows a striking development of cytoplasmic processes that interdigitate with similar processes from adjacent cells. Intercellular spaces form a system of interfacial channels providing a direct connection of the interstitial cell surface with blood vessels and the myoid layer of seminiferous tubules. Gonadotropic stimulation causes an increased number of free ribosomes and expansion of the Golgi complex and rough endoplasmic reticulum. There is a marked depletion of lipid droplets and formation of lipofuscin granules.