Nanoengineered Colloidal Inks for 3D Bioprinting
Nanoengineered Colloidal Inks for 3D Bioprinting
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DOI：
10.1021/acs.langmuir.7b02540
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发表时间：
2018-01-23
期刊：
影响因子：
3.9
通讯作者：
Gaharwar, Akhilesh K.
中科院分区：
文献类型：
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作者：
Peak, Charles W.;Stein, Jean;Gaharwar, Akhilesh K.
纳米工程水凝胶提供了为三维(3D)生物打印设计剪切稀释生物墨水的潜力。在这里，我们合成了由盘状二维(2D)纳米硅酸盐(Lapointe)和聚乙二醇(PEG)组成的胶体生物墨水。膨润土的加入增强了聚乙二醇网络，提高了粘度、储存模数和网络稳定性。由于内部相的快速重排，聚乙二烯-磷灰石水凝胶表现出剪切变稀和自恢复的特性。因此，可以使用聚乙二醇酯生物油墨打印一系列复杂的图案。与铸态结构相比，3D生物打印结构具有相似的机械性能。此外，在聚乙二醇脂云母生物墨水中包裹的细胞在生物打印后显示出较高的活力。总体而言，这项研究介绍了一种用于生物打印和细胞传递的新型聚乙二醇脂云母胶体油墨。
Nanoengineered hydrogels offer the potential to design shear-thinning bioinks for three-dimensional (3D) bioprinting. Here, we have synthesized colloidal bioinks composed of disk-shaped two-dimensional (2D) nanosilicates (Lapointe) and poly(ethylene glycol) (PEG). The addition, of Laponite reinforces the PEG network and increases viscosity, storage modulus, and network stability. PEG-Laponite hydrogels display shear-thinning and self-recovery characteristics due to rapid internal phase rearrangement. As a result, a range of complex patterns can be printed using PEG-Laponite bioinks. The 3D bioprinted structure has similar mechanical properties compared to the as-casted structure. In addition, encapsulated cell's within the PEG-Laponite bioink show high viability after bioprinting. Overall, this study introduces a new class of PEG-Laponite colloidal inks for bioprinting and cell delivery.