Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) is of prognostic value for survival in non-small cell lung cancer (NSCLC) -: A systematic review and meta-analysis (MA) by the European lung cancer working party for the IASLC lung cancer staging project
Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) is of prognostic value for survival in non-small cell lung cancer (NSCLC) -: A systematic review and meta-analysis (MA) by the European lung cancer working party for the IASLC lung cancer staging project
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DOI：
10.1097/jto.0b013e31815e6d6b
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发表时间：
2008-01-01
影响因子：
20.4
通讯作者：
Sculier, Jean-Paul
中科院分区：
文献类型：
--
作者：
Berghmans, Thierry;Dusart, Michele;Sculier, Jean-Paul
假设：2-[F-18]-氟-2-脱氧-D-葡萄糖正电子发射断层扫描是一种评估非小细胞肺癌（NSCLC）临床肿瘤、淋巴结、转移的成像工具。原发性肿瘤标准化摄取值（SUV）已被研究作为一个潜在的预后因素的生存。然而，样本量是有限的，导致进行荟萃分析，以提高精度估计其effect.Methods：我们进行了系统的文献检索。对于每一个出版物，我们提取了一个估计的风险比（HR）比较患者的低和高SUV，我们汇总到一个合并的HR，使用随机效应model.Results：我们发现13个合格的研究致力于非小细胞肺癌。其中大多数包括I期至III/IV期患者，并使用根据体重校正的SUV评估。患者数量范围为38至315例（总计：1474例）; 11项研究将高SUV确定为生存不良预后因素，尽管两项研究发现SUV与生存之间无显著相关性。定义高SUV的SUV测量和SUV阈值具有研究依赖性，8项研究寻找所谓的最佳截止值（最大化对数秩检验统计量），而未调整多重性的p值。总体而言，13份报告的合并HR为2.27（95%置信区间[CI]：1.70 - 3.02）;排除提出"最佳"临界值的研究，该值为2.08结论：原发灶SUV测量对NSCLC的预后有一定的预测价值;这些结果应在对个体患者数据的荟萃分析中得到证实。
Hypothesis: The 2-[F-18]-fluoro-2-deoxy-D-glucose positron emission tomography is an imaging tool for assessing clinical tumor, node, metastasis in non-small cell lung cancer (NSCLC). Primary tumor standardized uptake value (SUV) has been studied as a potential prognostic factor for survival. However, the sample sizes are limited leading to conduct a meta-analysis to improve the precision in estimating its effect.Methods: We performed a systematic literature search. For each publication, we extracted an estimate of the hazard ratio (HR) for comparing patients with a low and a high SUV and we aggregated the individual HRs into a combined HR, using a random-effects model.Results: We found 13 eligible studies dedicated to NSCLC. Most of them included patients with stages I to III/IV and used a SUV assessment corrected for body weight. Number of patients ranged from 38 to 315 (total: 1474); 11 studies identified a high SUV as a poor prognostic factor for survival although two studies found no significant correlation between SUV and survival. SUV measurement and SUV threshold for defining high SUV were study dependent, eight studies looked for a so-called best cutoff (maximizing the logrank test statistic) without adjusting the p value for multiplicity. Overall, the combined HR for the 13 reports was 2.27 (95% confidence interval [CI]: 1.70-3.02); excluding the studies proposing a "best" cutoff, it was 2.08 (95% CI: 1.431-3.04).Conclusion: Our meta-analysis suggests that the primary tumor SUV measurement has a prognostic value in NSCLC; these results should be confirmed in a meta-analysis on individual patients' data.