Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers.
Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers.
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DOI：
10.1038/s41598-020-77093-z
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发表时间：
2020-11-19
影响因子：
4.6
通讯作者：
Narain S
中科院分区：
文献类型：
--
作者：
Jain A;Chaurasia R;Sengar NS;Singh M;Mahor S;Narain S
COVID-19的特点是临床严重程度的显著变化。维生素D最近被认为是可能影响COVID-19严重程度的因素之一。本研究旨在分析COVID-19患者的维生素D水平及其对疾病严重程度的影响。经M.L.B医学院伦理委员会批准后，本研究作为为期6周的连续前瞻性观察性研究进行。参与者是在6周研究期间住院的30-60岁年龄组的COVID-19患者。研究包括无症状的COVID-19患者（A组）或需要入住ICU的重症患者（B组）。测定血清25（OH）D_3、IL-6、TNFα和血清铁蛋白。进行标准统计分析以分析差异。本研究入组了154例患者，A组91例，B组63例。A组维生素D平均水平（ng/mL）为27.89 ± 6.21，B组为14.35 ± 5.79，差异有高度显著性。A组和B组维生素D缺乏率分别为32.96%和96.82%。在总共154名患者中，发现90名患者缺乏维生素D（A组：29名; B组：61名）。发现维生素D缺乏的COVID-19患者的血清炎症标志物水平较高，即IL-6水平（单位：pg/mL）19.34 ± 6.17 vs 12.18 ± 4.29;血清铁蛋白319.17 ± 38.21 ng/mL vs 186.83 ± 20.18 ng/mL; TNFα水平（pg/mL）13.26 ± 5.64 vs 11.87 ± 3.15。维生素D缺乏者病死率高（21%比3.1%）。严重的COVID-19患者的维生素D水平明显较低。维生素D缺乏的COVID-19患者的炎症反应很高。这一切都转化为维生素D缺乏的COVID-19患者的死亡率增加。根据当前COVID-19大流行的灵活方法，作者建议向有COVID-19风险的人群大规模补充维生素D。
COVID-19 is characterized by marked variability in clinical severity. Vitamin D had recently been reviewed as one of the factors that may affect the severity in COVID-19. The objective of current study is to analyze the vitamin D level in COVID-19 patients and its impact on the disease severity. After approval from Ethics Committee, M.L.B Medical College the current study was undertaken as continuous prospective observational study of 6 weeks. Participants were COVID-19 patients of age group 30–60 years admitted during the study period of 6 weeks. Study included either asymptomatic COVID-19 patients (Group A) or severely ill patients requiring ICU admission (Group B). Serum concentration of 25 (OH)D, were measured along with serum IL-6; TNFα and serum ferritin. Standard statistical analysis was performed to analyze the differences. Current Study enrolled 154 patients, 91 in Group A and 63 patients in Group B. The mean level of vitamin D (in ng/mL) was 27.89 ± 6.21 in Group A and 14.35 ± 5.79 in Group B, the difference was highly significant. The prevalence of vitamin D deficiency was 32.96% and 96.82% respectively in Group A and Group B. Out of total 154 patients, 90 patients were found to be deficient in vitamin D (Group A: 29; Group B: 61). Serum level of inflammatory markers was found to be higher in vitamin D deficient COVID-19 patients viz. IL-6 level (in pg/mL) 19.34 ± 6.17 vs 12.18 ± 4.29; Serum ferritin 319.17 ± 38.21 ng/mL vs 186.83 ± 20.18 ng/mL; TNFα level (in pg/mL) 13.26 ± 5.64 vs 11.87 ± 3.15. The fatality rate was high in vitamin D deficient (21% vs 3.1%). Vitamin D level is markedly low in severe COVID-19 patients. Inflammatory response is high in vitamin D deficient COVID-19 patients. This all translates into increased mortality in vitamin D deficient COVID-19 patients. As per the flexible approach in the current COVID-19 pandemic authors recommend mass administration of vitamin D supplements to population at risk for COVID-19.
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DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
--
作者：
Magro, Giuseppe
通讯作者：
Magro, Giuseppe
DOI：
10.1136/bmj.i6583
发表时间：
2017-02-15
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Martineau AR;Jolliffe DA;Hooper RL;Greenberg L;Aloia JF;Bergman P;Dubnov-Raz G;Esposito S;Ganmaa D;Ginde AA;Goodall EC;Grant CC;Griffiths CJ;Janssens W;Laaksi I;Manaseki-Holland S;Mauger D;Murdoch DR;Neale R;Rees JR;Simpson S Jr;Stelmach I;Kumar GT;Urashima M;Camargo CA Jr
通讯作者：
Camargo CA Jr
影响因子：
5.4
作者：
Carpagnano, G. E.;Di Lecce, V;Resta, O.
通讯作者：
Resta, O.
影响因子：
9.8
作者：
Hill, Michael A.;Mantzoros, Christos;Sowers, James R.
通讯作者：
Sowers, James R.