TRANSLOCATION JOINS C-MYC AND IMMUNOGLOBULIN-GAMMA-1 GENES IN A BURKITT-LYMPHOMA REVEALING A 3RD EXON IN THE C-MYC ONCOGENE
TRANSLOCATION JOINS C-MYC AND IMMUNOGLOBULIN-GAMMA-1 GENES IN A BURKITT-LYMPHOMA REVEALING A 3RD EXON IN THE C-MYC ONCOGENE
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DOI：
10.1038/304135a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
RABBITTS, TH
中科院分区：
文献类型：
--
作者：
HAMLYN, PH;RABBITTS, TH
重组DNA克隆用于直接证明伯基特淋巴瘤细胞系Raji，t（8;14）（q24;q32）具有与人IG H链基因座的γ 1恒定区基因相邻的c-myc基因的重排拷贝;基因以相反的转录方向排列。通过RNA转录物分析，在正常c-myc基因中检测到至少一个另外的5“外显子，并且描述了高水平的2个c-myc mRNA大小类的发生，这两个大小类都明显起始于该外显子。
Recombinant DNA clones were used to directly demonstrate that the Burkitt lymphoma cell line Raji, t(8;14) (q24;q32), has a rearranged copy of the c-myc gene adjacent to the .gamma.1 constant region gene of the human Ig H-chain locus; the genes are arranged in the opposite direction for transcription. At least one further 5'' exon was detected in the normal c-myc gene by analysis of RNA transcripts, and the occurrence of high levels of 2 c-myc mRNA size classes, both apparently initiating in this exon, is described.