Long-term Absolute Risk for Cardiovascular Disease Stratified by Fasting Glucose Level
Long-term Absolute Risk for Cardiovascular Disease Stratified by Fasting Glucose Level
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DOI：
10.2337/dc18-1773
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发表时间：
2019-03-01
期刊：
影响因子：
16.2
通讯作者：
Wilkins, John T.
中科院分区：
文献类型：
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作者：
Bancks, Michael P.;Ning, Hongyan;Wilkins, John T.
目的根据空腹血糖（FG）水平低于糖尿病阈值估计心血管疾病（CVD）的长期绝对风险。研究设计和方法我们汇总了1960年至2015年美国黑人和白色男性和女性的7个观察队列的数据。我们将FG分类如下：≥ 7.0 mmol/L或使用糖尿病药物）。CVD定义为致死性/非致死性冠心病和致死性/非致死性卒中。我们使用改良的Kaplan-Meier生存分析，根据FG类别估计了指数年龄55岁时CVD的风险，并对非CVD死亡的竞争风险进行了调整。我们还根据50岁之前FG的变化评估了心血管疾病事件的风险，特别是在以下类别中
OBJECTIVE To estimate the long-term absolute risk for cardiovascular disease (CVD) according to fasting glucose (FG) levels below the threshold of diabetes. RESEARCH DESIGN AND METHODS We pooled data from seven observational cohorts of U.S. black and white men and women followed from 1960 to 2015. We categorized FG as follows: = 7.0 mmol/L or use of diabetes medications). CVD was defined as fatal/nonfatal coronary heart disease and fatal/nonfatal stroke. We estimated the risk of CVD by FG category at index age 55 years using a modified Kaplan-Meier survival analysis, adjusted for the competing risk of non-CVD death. We also assessed risk for incident CVD according to change in FG before 50 years of age, specifically among the categories