Acute allergic reactions in children with AEDS after prolonged cow's milk elimination diets
Acute allergic reactions in children with AEDS after prolonged cow's milk elimination diets
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DOI：
10.1111/j.1398-9995.2006.01018.x
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发表时间：
2006-03-01
期刊：
影响因子：
12.4
通讯作者：
Pasmans, SGMA
中科院分区：
文献类型：
--
作者：
Flinterman, AE;Knulst, AC;Pasmans, SGMA
背景资料：食物过敏并不总是正确诊断儿童特应性湿疹皮炎综合征（AEDS）和治疗与回避饮食是不是没有danger.Methods：入院后，我们的诊所，11名儿童长期牛奶（CM）消除饮食，因为AEDS和致敏进行了双盲安慰剂对照的食物挑战（DBPCFC）。仔细记录了逆转录、CM暴露、致敏和意外摄入反应。DBPCFC被用来评估儿童的现状。结果：消除期前（中位数2.3年，入院前开始），所有11名儿童与AEDS致敏，并已摄入CM（4瓶喂养，7母乳喂养的母亲没有CM饮食）的急性反应的发展。DBPCFC先前未证实CM过敏的诊断。消除后，AED没有改善，但仍继续饮食。在消除期间，11名儿童中有8名在意外摄入CM后发生严重的急性过敏反应。在评估中，在我们的诊所，所有11名儿童经历了急性过敏反应，CM在DBPCFC.Conclusion：有相当大的机会发展急性过敏反应CM消除后，在儿童AEDS没有以前的问题后，CM摄入量。
Background: Food allergy is not always correctly diagnosed in children with atopic eczema dermatitis syndrome (AEDS) and treatment with an avoidance diet is not without danger.Methods: After admission to our clinic, 11 children with a prolonged cow's milk (CM) elimination diet because of AEDS and sensitization underwent double-blind placebo-controlled food challenge (DBPCFC). Retrospectively, the exposure to CM, sensitization and reactions to accidental ingestion were carefully documented. The DBPCFC was used to evaluate the childrens' current status.Results: Before the elimination period (median 2.3 years; started before the admission) all 11 children with AEDS were sensitized and had ingested CM (four bottle-fed; seven breast-fed without CM diet of the mother) without the development of acute reactions. The diagnosis of CM allergy was not confirmed by DBPCFC previously. After elimination the AEDS had not improved, but nevertheless the diet was continued. During the elimination period, eight of 11 children developed severe acute allergic reactions to CM after accidental ingestion. In evaluation, in our clinic all 11 children experienced acute allergic reactions to CM during DBPCFC.Conclusion: There is a considerable chance of developing acute allergic reactions to CM after elimination in children with AEDS without previous problems after CM intake.