Effects of human granulocyte colony-stimulating factor in a patient with idiopathic neutropenia.
Effects of human granulocyte colony-stimulating factor in a patient with idiopathic neutropenia.
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人粒细胞集落刺激因子对特发性中性粒细胞减少症患者的影响。
DOI：
10.1056/nejm198901053200107
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Gabrilove,J
中科院分区：
文献类型：
--
作者：
Jakubowski,AA;Souza,L;Kelly,F;Fain,K;Budman,D;Clarkson,B;Bonilla,MA;Moore,MA;Gabrilove,J
慢性特发性中性粒细胞减少症的特点是骨髓中中性粒细胞前体的成熟停滞和循环中性粒细胞计数低于每微升1500个细胞。其他造血细胞计数正常，无抗中性粒细胞抗体。临床上，患者有粘膜溃疡、牙周病和间歇性感染。对症或预防性抗生素治疗一直是主要的治疗方法。造成中性粒细胞减少症的原因尚不清楚。虽然早期的研究表明，患者尿液和血清中的集落刺激活性与正常人相似，但特异性集落刺激因子的产生尚未得到评估。
CHRONIC idiopathic neutropenia is characterized by maturational arrest of neutrophil precursors in the bone marrow and a circulating neutrophil count of less than 1500 cells per microliter. Other hematopoietic cell counts are usually normal, and antineutrophil antibodies are absent. Clinically, patients have mucosal ulcerations, periodontal disease, and intermittent infections. Symptomatic or prophylactic treatment with antibiotics has been the mainstay of therapy.The cause of this neutropenia is unknown. Although early studies suggested that colony-stimulating activity in the urine and serum of patients was similar to that found in normal persons,1the production of specific colony-stimulating factors has not been evaluated. . . .