REAPPRAISAL OF THE RESULTS OF STOPPING THERAPY IN CHILDHOOD LEUKEMIA
REAPPRAISAL OF THE RESULTS OF STOPPING THERAPY IN CHILDHOOD LEUKEMIA
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DOI：
10.1056/nejm197902083000601
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
SIMONE, JV
中科院分区：
文献类型：
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作者：
GEORGE, SL;AUR, RJA;SIMONE, JV
对儿童急性淋巴细胞白血病停药[化疗和放疗]的结果进行了检查。在8个连续的总治疗研究的639例患者中，278例（44%）停止了所有治疗，通常在完全缓解2年半后。这组人中约有五分之一（278人中的55人）复发，主要是在骨髓中。停药第1年的复发率高于随后3年的复发率（0.16比0.04，P < 0.01）。所有患者的第4年复发率的寿命表估计值为0.24，接受充分中枢神经系统预防的患者为0.22。男孩复发率高于女孩（0.33比0.15，P < 0.01）。79例患者中，至少4年的治疗仍保持完全缓解，但尚未复发。急性淋巴细胞性白血病在接受治疗约2年半的所有新诊断患者中有超过三分之一是可治愈的。
The results of stopping therapy [chemotherapy and radiotherapy] in children with acute lymphocytic leukemia were examined. Of 639 patients in 8 consecutive total therapy studies, 278 (44%) had all treatment stopped, usually after 2 1/2 yr of complete remission. About one fifth (55 of 278) of this group have relapsed, mainly in the bone marrow. The relapse rate for the 1st yr off therapy was higher than that for the next 3 yr (0.16 vs. 0.04, P < 0.01). The life-table estimates of the 4th-yr relapse rates were 0.24 for all patients and 0.22 for patients receiving adequate central-nervous-system prophylaxis. Boys had a higher relapse rate than girls (0.33 vs. 0.15, P < 0.01). None of the 79 patients who remained in complete remission for at least 4 yr off therapy have yet relapsed. Acute lymphocytic leukemia appears curable in over one third of all newly diagnosed patients who receive treatment for approximately 2 1/2 yr.