Protein corona formed in the gastrointestinal tract and its impacts on oral delivery of nanoparticles
Protein corona formed in the gastrointestinal tract and its impacts on oral delivery of nanoparticles
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DOI：
10.1002/med.21767
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发表时间：
2020-12
影响因子：
13.3
通讯作者：
Tianxu Zhang;GuanYin Zhu;Boyao Lu;Z. Qian;Q. Peng
中科院分区：
文献类型：
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作者：
Tianxu Zhang;GuanYin Zhu;Boyao Lu;Z. Qian;Q. Peng
纳米粒子与蛋白质的相互作用以及蛋白质在生物体液中形成蛋白质冠对于药物传递具有重要意义。在过去的十年中，冠在血液中的形成和它的影响，在体外和体内的命运的纳米粒子已经得到了很好的研究和审查。近年来，口服纳米粒与消化酶在胃肠道内的相互作用越来越受到人们的关注。GIT中形成的酶冠可以显著影响NP的性质、胃肠道转运和口服吸收。由于口服递送是最优选的递送途径，因此全面了解GIT中的电晕形成及其对口服递送NP的影响是非常重要的。在此，我们的目的是总结最近更新的纳米蛋白和消化酶之间的相互作用，并启动一个有趣的讨论，利用消化酶冠结肠靶向输送的潜力。
The interaction of nanoparticles (NPs) with proteins and the formation of protein corona in the biological fluids are of great interest and significance for drug delivery. In the past decade, the corona formation in the blood and its impacts on the in vitro and in vivo fate of NPs has been well investigated and reviewed. Recently, more and more attention is paid to the nano–protein interactions taking place in the gastrointestinal tract (GIT) between the orally administered NPs and the digestive enzymes. The enzyme corona formed in the GIT can significantly affect the properties, gastrointestinal transit, and oral absorption of NPs. Since oral delivery is the most preferred delivery route, comprehensively understanding the corona formation in the GIT and its impacts on oral delivery NPs are of great importance. Herein, we aim to summarize the recent updates on the nano–protein interactions between NPs and digestive enzymes, and launch an interesting discussion on the potentials of using the digestive enzyme corona for the colon targeted delivery.