Clinical correlates of awareness for balance, function, and memory: evidence for the modality specificity of awareness.
Clinical correlates of awareness for balance, function, and memory: evidence for the modality specificity of awareness.
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DOI：
10.1155/2014/674716
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发表时间：
2014
影响因子：
4.7
通讯作者：
Morgan D
中科院分区：
文献类型：
--
作者：
O'Connell ME;Dal Bello-Haas V;Crossley M;Morgan D
人们越来越认识到痴呆症不仅是多因素的，而且是特定领域的。我们展示了日常功能意识，记忆意识和平衡意识的新探索的差异临床相关性。轻度认知障碍（aMCI和非aMCI）参与者的功能意识高于痴呆患者（由于阿尔茨海默病；AD和非AD），而非aMCI和非AD痴呆患者的记忆意识高于aMCI或AD患者。平衡意识在诊断亚组之间没有差异。功能意识与日常生活工具活动和照顾者负担有关。相比之下，平衡意识与跌倒史、平衡信心和日常生活的工具活动有关。记忆意识的临床相关性依赖于诊断组：非阿尔茨海默氏症痴呆与神经心理学变量存在关联，但对于阿尔茨海默氏症痴呆患者，抑郁和日常生活的工具性活动是记忆意识的临床相关性。总之，这些数据支持了意识和痴呆不是单一的假设，而是特定于模式的假设。
Awareness in dementia is increasingly recognized not only as multifactorial, but also as domain specific. We demonstrate differential clinical correlates for awareness of daily function, awareness of memory, and the novel exploration of awareness of balance. Awareness of function was higher for participants with mild cognitive impairment (aMCI and non-aMCI) than for those with dementia (due to Alzheimer disease; AD and non-AD), whereas awareness of memory was higher for both non-aMCI and non-AD dementia patients than for those with aMCI or AD. Balance awareness did not differ based on diagnostic subgroup. Awareness of function was associated with instrumental activities of daily living and caregiver burden. In contrast, awareness of balance was associated with fall history, balance confidence, and instrumental activities of daily living. Clinical correlates of awareness of memory depended on diagnostic group: associations held with neuropsychological variables for non-AD dementia, but for patients with AD dementia, depression and instrumental activities of daily living were clinical correlates of memory awareness. Together, these data provide support for the hypothesis that awareness and dementia are not unitary and are, instead, modality specific.