tbx20 a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish
tbx20 a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish
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DOI：
10.1016/s0925-4773(00)00346-4
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发表时间：
2000-07-01
影响因子：
2.6
通讯作者：
Ho, RK
中科院分区：
文献类型：
--
作者：
Ahn, D;Ruvinsky, I;Ho, RK
T-box基因是一个转录调控基因家族，参与多种发育过程，从胚层的形成到中枢神经系统的区域化。在这篇报道中，我们描述了一个新的斑马鱼T-box基因的克隆和表达模式，我们将其命名为tbx20。Tbx20是从黑腹果蝇H15和秀丽线虫Tbx-12不同门类动物中分离得到的另外两个T-box基因的同源基因，表明该基因的进化起源早于原口和后口的分化。在发育过程中，tbx20在中胚层和外胚层的胚胎结构中都有表达，包括心脏、颅运动神经元和背主动脉顶端。(C)2000爱思唯尔爱尔兰科学有限公司。保留所有权利。
The T-box genes constitute a family of transcriptional regulator genes that have been implicated in a variety of developmental processes ranging from the formation of germ layers to the regionalization of the central nervous system. In this report we describe the cloning and expression pattern of a new T-box gene from zebrafish, which we named tbx20. tbx20 is an ortholog of two other T-box genes isolated from animals of different phyla - H15 of Drosophila melanogaster and tbx-12 of Caenorhabditis elegans, suggesting that the evolutionary origin of this gene predates the divergence between the protostomes and deuterostomes. During development, tbx20 is expressed in embryonic structures of both mesodermal and ectodermal origins, including the heart, cranial motor neurons, and the roof of the dorsal aorta. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.