Nosocomial transmission of Clostridium difficile Genotype ST81 in a General Teaching Hospital in China traced by whole genome sequencing.
Nosocomial transmission of Clostridium difficile Genotype ST81 in a General Teaching Hospital in China traced by whole genome sequencing.
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通过全基因组测序追踪中国某综合教学医院基因型 ST81 艰难梭菌的院内传播
DOI：
10.1038/s41598-017-09878-8
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发表时间：
2017-08-29
影响因子：
4.6
通讯作者：
Li M
中科院分区：
文献类型：
--
作者：
Qin J;Dai Y;Ma X;Wang Y;Gao Q;Lu H;Li T;Meng H;Liu Q;Li M
艰难梭菌感染（CDI）在全球范围内日益被认为是导致严重发病率和死亡率的原因。本研究的目的是提供洞察的各种动力学的C。医院内的传播和感染。我们监测了C. 2014年5月至2015年8月期间，在中国上海的一家教学医院中，使用艰难梭菌菌株确定随时间推移的流行病学。2015年5月和6月，住院患者和门诊患者的CDI发生率分别为67.7例/10万患者日和0.3例/10万患者日，存在院内患者-环境-患者传播。C.艰难梭菌基因型ST 81（tcdA阴性，tcdB阳性）不仅是最常见的菌株（30.8%（28/91）），而且对克林霉素和阿氟沙星的耐药率也明显高于非ST 81基因型。感染ST 81基因型的住院患者年龄超过65岁，合并症较多，但感染ST 81的患者临床症状较非ST 81感染患者少。这项研究提供了初步的流行病学证据，C。艰难梭菌ST 81是一种成功的流行基因型，值得在中国持续监测。
Clostridium difficile infection (CDI) is increasingly recognized globally as a cause of significant morbidity and mortality. This study aimed to provide insight into the various dynamics of C. difficile transmission and infection in the hospital. We monitored the toxin and resistance profiles as well as evolutionary relationships of C. difficile strains to determine the epidemiology over time in a teaching hospital in Shanghai, China between May 2014 and August 2015. The CDI incidence of inpatients and outpatients were 67.7 cases and 0.3 cases per 100,000 patient-days, with a nosocomial patient-environment-patient transmission in May and June 2015. C. difficile genotype ST81, a clone with tcdA-negative and tcdB-positive, was not only the most common strain (30.8%, 28/91) but also had much higher resistance rates to clindamycin and moxifloxacin compared with non-ST81 genotypes. Hospitalized patients infected with ST81 genotypes were over 65 years of age and had more comorbidities, however patients infected with ST81 presented with less clinical symptoms than non-ST81 infected patients. This study provides initial epidemiological evidence that C. difficile ST81 is a successful epidemic genotype that deserves continuous surveillance in China.
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中国上海一家三级医院艰难梭菌感染的临床和微生物学特征
影响因子：
6.1
作者：
Dong Danfeng;Peng Yibing;Mao Enqiang
通讯作者：
Mao Enqiang
影响因子：
7
作者：
Li, Ruiqiang;Zhu, Hongmei;Wang, Jun
通讯作者：
Wang, Jun
影响因子：
--
作者：
Kim, Heejung;Jeong, Seok Hoon;Lee, Kyungwon
通讯作者：
Lee, Kyungwon
DOI：
10.3343/kjlm.2011.31.3.191
发表时间：
2011-07
期刊：
The Korean journal of laboratory medicine
影响因子：
--
作者：
Kim H;Lee Y;Moon HW;Lim CS;Lee K;Chong Y
通讯作者：
Chong Y
DOI：
10.1093/cid/cit127
发表时间：
2013-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Walker AS;Eyre DW;Wyllie DH;Dingle KE;Griffiths D;Shine B;Oakley S;O'Connor L;Finney J;Vaughan A;Crook DW;Wilcox MH;Peto TE;Infections in Oxfordshire Research Database
通讯作者：
Infections in Oxfordshire Research Database