Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progression
Comparison of intravascular ultrasound and quantitative coronary angiography for the assessment of coronary artery disease progression
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DOI：
10.1161/circulationaha.106.655654
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发表时间：
2007-04-10
期刊：
影响因子：
37.8
通讯作者：
Tardif, Jean-Claude
中科院分区：
文献类型：
--
作者：
Berry, Colin;L'Allier, Philippe L.;Tardif, Jean-Claude
背景-冠状动脉定量分析（QCA）和血管内超声（IVUS）评估冠状动脉疾病进展/消退的相对优势尚不确定。为了进一步探讨这个问题，我们分析了血管造影和IVUS数据来自当代临床试验population.Methods和结果-我们调查了QCA和IVUS之间的关系在单个时间点（n = 525），也随着时间的变化（n = 432）。对QCA和IVUS数据进行中心实验室分析。对于匹配的节段，QCA冠状动脉评分与IVUS导出的管腔体积（r = 0.65，P < 0.0001）和总血管体积（r = 0.55，P < 0.0001）之间以及QCA累积冠状动脉狭窄评分与基线时IVUS上的动脉粥样硬化体积百分比（r = 0.32，P < 0.0001）之间存在统计学显著相关性。对于全局（所有节段）QCA衍生数据和单血管IVUS衍生数据，观察到相似的相关性模式。QCA和IVUS管腔尺寸随时间的变化（P = 0.005）以及QCA累积冠状动脉狭窄评分变化与IVUS动脉粥样硬化体积百分比之间存在统计学显著但弱相关性（r = 0.14，P = 0.01）。然而，血管造影进展和无血管造影进展的患者在IVUS上斑块体积的变化分别为9.13和0.20 mm（3）（P = 0.028）。结论-- QCA和IVUS测量的管腔尺寸在单个时间点和随时间的变化是相关的。尽管动脉粥样硬化体积百分比的变化与作为连续变量的QCA变化仅弱相关，但与无血管造影进展相比，QCA疾病进展与IVUS斑块体积显著增加相关。
Background - The relative merits of quantitative coronary analysis (QCA) and intravascular ultrasound (IVUS) for the assessment of progression/regression in coronary artery disease are uncertain. To explore this subject further, we analyzed the angiographic and IVUS data derived from a contemporary clinical trial population.Methods and Results - We investigated the relationships between QCA and IVUS at single time points (n = 525) and also for the changes over time (n = 432). QCA and IVUS data underwent central laboratory analyses. Statistically significant correlations were observed between the QCA coronary artery score and the IVUS-derived lumen volume (r = 0.65, P < 0.0001) and total vessel volume (r = 0.55, P < 0.0001) and between the QCA cumulative coronary stenosis score and percent atheroma volume on IVUS (r = 0.32, P < 0.0001) at baseline for matched segments. A similar pattern of correlations was observed for global (all segments) QCA-derived and single-vessel IVUS-derived data. There were statistically significant but weak correlations between the changes over time in lumen dimensions on QCA and IVUS (P = 0.005) and between the change in cumulative coronary stenosis score on QCA and percent atheroma volume on IVUS (r = 0.14, P = 0.01). Nevertheless, patients with and without angiographic progression had changes in plaque volume on IVUS of 9.13 and 0.20 mm(3), respectively (P = 0.028).Conclusions - QCA- and IVUS-derived measures of lumen dimensions are correlated at single time points and for changes over time. Although the change in percent atheroma volume is only weakly correlated with QCA changes as continuous variables, disease progression on QCA is associated with significant increases in plaque volume on IVUS compared with no angiographic progression.