Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults
Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults
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DOI：
10.1093/geronb/62.2.p112
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发表时间：
2007-03-01
影响因子：
6.2
通讯作者：
Nilsson, Lars-Goeran
中科院分区：
文献类型：
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作者：
de Frias, Cindy M.;Bunce, David;Nilsson, Lars-Goeran
我们使用来自桦木研究的数据来检查总胆固醇、甘油三酯和载脂蛋白 E 与 10 年认知能力变化之间的关联。对 524 名非痴呆成年人（初始年龄 55-80 岁）进行了评估情景记忆（回忆和识别）、语义记忆（知识和流畅性）和视觉空间能力（块设计）的测试；对数据应用多级建模。较高的甘油三酯水平与言语知识的下降有关。脂质水平调节了载脂蛋白E对情景记忆的影响，因此在ε4等位基因携带者中，胆固醇水平较高的个体的识别能力下降。胆固醇和甘油三酯水平是可药理学改变的危险因素，可解释正常认知衰老的变化。
We used data from the Betula Study to examine associations between total cholesterol, triglycerides, and apolipoprotein E on 10-year changes in cognitive performance. Tests assessing episodic memory (recall and recognition), semantic memory (knowledge and fluency), and visuospatial ability (block design) were administered to 524 nondemented adults (initial age of 55-80 years); multilevel modeling was applied to the data. Higher triglyceride levels were associated with a decline in verbal knowledge. Lipid levels moderated the influence of apolipoprotein E on episodic memory, such that among epsilon 4 allele carriers, decline in recognition was noted for individuals with higher cholesterol levels. Cholesterol and triglyceride levels are pharmacologically modifiable risk factors that account for variation In normal cognitive aging.