Exosomes: The Messengers of Health and Disease.
Exosomes: The Messengers of Health and Disease.
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DOI：
10.2174/1570159x14666160825160421
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发表时间：
2017
影响因子：
5.3
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Isola AL;Chen S
摘要：胞外体是由含有多种蛋白质、RNA和生物活性脂类的脂双层组成的小囊泡。它们充当细胞间的信使，使同一类型的两个细胞和其他类型的细胞之间能够进行通信。它们由健康细胞释放，既有结构性的，也有细胞激活的，在免疫系统功能中发挥重要作用。外切体对于健康的生理状态是必不可少的，然而在病理情况下，它们会增强细胞的应激和损伤。本文综述了这些纳米信息囊泡外切体的特征、生物发生、在疾病发病机制中的作用(S)和在癌症进展中的作用(S)。
Abstract: Exosomes are small vesicles comprised of a lipid bilayer containing various proteins, RNAs and bioactive lipids. They act as intercellular messengers that give the ability to communicate between both cells of the same type and other cell types. They are released by healthy cells, both constitutively and upon cell activation and play an important role in immune system function. Exosomes are essential for healthy physiological conditions, however under pathological circumstances, they act to potentiate cellular stress and damage. This review explores the characteristics, biogenesis, role(s) in the pathogenesis of diseases and role(s) in progression of cancer of these nano-sized messages-in-a-vesicle: exosomes.