The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study
The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study
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DOI：
10.1111/j.1537-2995.2004.03366.x
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发表时间：
2004-07-01
期刊：
影响因子：
2.9
通讯作者：
Borzini, P
中科院分区：
文献类型：
--
作者：
Mazzucco, L;Medici, D;Borzini, P
背景：慢性溃疡可以受益于生长因子（GF）的局部治疗。PLT凝胶提供组织再生诱导GF。本研究的目的是验证自体血小板凝胶在治疗不愈合的皮肤lesions.Study设计和方法的有效性：血小板凝胶是通过治疗血小板与自体凝血酶。研究了两组患者：胸骨伤口裂开患者和坏死性皮肤溃疡患者。对接受PLT凝胶治疗的患者与病变相似但接受常规治疗的患者进行回顾性比较。该研究的临床终点是愈合率、住院时间和/或进行重建整形手术所需的充分组织再生时间。结果：在接受治疗的胸骨裂开伤口患者中，（3.5 vs. 6.0周，p = 0.0002）和住院时间（31.5 vs. 52.5天，p < 0.0001）显著减少。接受治疗的坏死性皮肤溃疡患者需要的手术时间明显更短（中位数15.0 vs. 35.5周，p < 0.0001）。既没有不良反应，也没有原位复发observed.CONCLUSIONS：慢性不愈合伤口的患者表现出显着改善时，与PLT凝胶损伤敷料治疗。
BACKGROUND: Chronic ulcers can benefit from topical treatment with growth factors (GFs). PLT gel provides tissue regeneration-inducing GFs. The aim of this study was to verify the effectiveness of autologous PLT gel in the treatment of nonhealing skin lesions.STUDY DESIGN AND METHODS: PLT gel was produced by treating PLTs with autologous thrombin. Two groups of patients were investigated: patients with dehiscent sternal wounds and patients with necrotic skin ulcers. Patients treated with PLT gel were retrospectively compared with patients having similar lesions but undergoing conventional treatment. The clinical endpoints of the study were the healing rate, the length of hospital stay, and/or the time required to bring about adequate tissue regeneration in order to undergo reconstructive plastic surgery.RESULTS: In patients with treated dehiscent sternal wounds the healing rate (3.5 vs. 6.0 wks, p = 0.0002) and hospital stay (31.5 vs. 52.5 days, p < 0.0001) were significantly reduced. Patients with treated necrotic skin ulcers required a notably shorter time to have surgery (median 15.0 vs. 35.5 wks, p < 0.0001). Neither adverse reactions nor in-situ recurrences were observed.CONCLUSIONS: Patients with chronic unhealing wounds showed substantial improvement when treated with PLT gel lesion dressings.