Porcine aortic surgical model to study isolated intraspinal collateralization.
Porcine aortic surgical model to study isolated intraspinal collateralization.
复制标题
研究孤立性椎管内侧支循环的猪主动脉手术模型
DOI：
10.1016/j.jtcvs.2015.03.001
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Beyersdorf F
中科院分区：
文献类型：
--
作者：
Kari FA;Siepe M;Beyersdorf F
背景广泛主动脉手术中脊髓缺血的发生率仍高达15%~ 20%。根据个体侧支解剖结构进行术前风险预测目前是不可能的。猪模型已被建立为研究主动脉手术环境中脊髓侧支生理学的宝贵机会。1脊髓侧支网络的椎管内室包括一系列的圆弧和前根髓动脉（ARMA）1，功能尚未得到表征。我们假设一个重要的贡献，这个系统立即恢复足够的脊髓灌注压后，直接连续闭塞节段性血管。我们试图建立一个大型动物模型，脊髓侧支血流仅通过脊柱内系统输送。在一项概念验证研究中，通过经皮乙醇消融背段动脉实现了胸腰椎椎旁流入的关闭。其目的是建立一个模型，适用于调查的椎管内侧支系统在隔离，更清楚地了解其作用，在主动脉手术期间保持足够的脊髓灌注。
BackgroundThe incidence of spinal cord ischemia during extensive aortic surgery is still reported to be as high as 15% to 20%. Preoperative risk prediction according to individual collateral anatomy is not currently possible. The porcine model has been established as a valuable opportunity to study spinal collateral physiology in an aortic surgical setting. 1 The intraspinal compartment of the spinal collateral network includes a serial pattern of circular arcades and anterior radiculomedullary arteries (ARMAs) 1 and has not yet been functionally characterized. We postulate an important contribution of this system to immediate recovery of a sufficient spinal cord perfusion pressure directly after serial occlusion of segmental vessels. We sought to create a large animal model with spinal collateral flow being exclusively delivered through the intraspinal system. In a proof-of-concept study, a shutdown of thoracic and lumbar paraspinous inflow was achieved through percutaneous ethanol ablation of dorsal segmental arteries. The goal was to create a model suitable for investigation of the intraspinal collateral system in isolation, to understand more clearly its role in maintaining adequate spinal cord perfusion during aortic surgery.
影响因子：
3.5
作者：
R. Nijenhuis;W. Backes
通讯作者：
W. Backes