Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison
Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison
复制标题
耳后皮下注射治疗内耳疾病：使用磁共振成像和药代动力学比较的实验可行性研究
DOI：
10.1017/s0022215113000017
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发表时间：
2013-03-01
影响因子：
1.7
通讯作者：
Jing, Y.
中科院分区：
文献类型：
--
作者：
Li, J.;Yu, L.;Jing, Y.
摘要背景：为了探讨耳后皮下注射治疗内耳疾病的可行性，我们利用磁共振成像技术，在动物模型中比较了耳后和静脉注射外淋巴液的药代动力学。方法：12只白化豚鼠随机分为两组，分别经耳后注射和静脉注射加多喷妥钠地葡胺。使用7.0Tesla磁共振成像系统评估耳蜗Gd增强图像的信号强度，以此作为外淋巴液中吉巴喷妥钠双葡胺浓度变化的生物标志物。根据这些信号强值计算药动学参数。结果：耳后注射的豚鼠表现出较长的信号峰值时间、较长的消除半衰期、较长的平均停留时间和较大的信号-时间曲线下面积(注射前至最后一个时间点)(p<；0.05)。结论：耳后注射是一种治疗内耳疾病的有效给药途径。
Abstract Background: To investigate the feasibility of postauricular hypodermic injection for treating inner ear disorders, we compared perilymph pharmacokinetics for postauricular versus intravenous injection, using magnetic resonance imaging, in an animal model. Methods: Twelve albino guinea pigs were divided randomly into two groups and administered gadopentetate dimeglumine via either a postauricular or an intravenous bolus injection. A 7.0 Tesla magnetic resonance imaging system was used to assess the signal intensities of gadolinium-enhanced images of the cochlea, as a biomarker for changes in gadopentetate dimeglumine concentration in the perilymph. Pharmacokinetic parameters were calculated based on these signal intensity values. Results: Guinea pigs receiving postauricular injection showed longer times to peak signal intensity, longer elimination half-life, longer mean residence time and a greater area under the signal–time curve (from pre-injection to the last time point) (p < 0.05). Conclusion: Postauricular injection shows potential as an efficient drug delivery route for the treatment of inner ear disorders.