Targeted Lesion Generation Through the Skull Without Aberration Correction Using Histotripsy.
Targeted Lesion Generation Through the Skull Without Aberration Correction Using Histotripsy.
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使用组织解剖学通过头骨生成有针对性的病变，无需像差校正。
DOI：
10.1109/tuffc.2016.2531504
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Cain,Charles
中科院分区：
文献类型：
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作者：
Sukovich,Jonathan;Xu,Zhen;Kim,Yohan;Cao,Hui;Nguyen,Thai-Son;Pandey,Aditya;Hall,Timothy;Cain,Charles
这项研究证明了组织解剖学能够在不使用像差校正的情况下通过颅骨产生目标病变。使用我们实验室制造的孔径直径为 30 厘米、焦距为 15 厘米的 500 kHz 256 元件半球形换能器进行组织解剖治疗。根据线性估计 (p-)LE，该传感器理论上能够在超过 200 MPa 的自由场中产生峰值稀疏压力，脉冲持续时间≤2 个声学周期。使用三个切除的人类头盖骨，在没有像差校正的情况下显示出 73%-81% 的声压衰减。通过所有三个头盖骨，使用估计的（p-）LE为28-39 MPa、脉冲重复频率为1 Hz、脉冲总数为300，在没有像差校正的红细胞琼脂糖组织模型中产生了半径小于1 mm的致密病变。随着头盖相对于换能器的位置变化，在换能器的几何焦点处一致地观察到病变的产生，并且通过机械调整头盖相对于换能器的位置以瞄准其中的不同区域，经颅产生多模式病变。这些结果表明，使用非常短的脉冲进行组织解剖，无需使用像差校正，可以通过完整的头盖骨生成具有清晰边界的紧凑目标病变。这种能力有可能大大简化非侵入性经颅应用的经颅超声治疗，因为当前的超声经颅治疗技术都需要复杂的像差校正。
This study demonstrates the ability of histotripsy to generate targeted lesions through the skullcap without using aberration correction. Histotripsy therapy was delivered using a 500-kHz 256-element hemispherical transducer with an aperture diameter of 30 cm, and a focal distance of 15 cm fabricated in our laboratory. This transducer is theoretically capable of producing peak rarefactional pressures, based on linear estimation, (p-)LE, in the free field in excess of 200 MPa with pulse durations ≤2 acoustic cycles. Three excised human skullcaps were used displaying attenuations of 73%-81% of the acoustic pressure without aberration correction. Through all three skullcaps, compact lesions with radii less than 1 mm were generated in red blood cell agarose tissue phantoms without aberration correction, using estimated (p-)LEof 28-39 MPa, a pulse repetition frequency of 1 Hz, and a total number of 300 pulses. Lesion generation was consistently observed at the geometric focus of the transducer as the position of the skullcap with respect to the transducer was varied, and multiple-patterned lesions were generated transcranially by mechanically adjusting the position of the skullcap with respect to the transducer to target different regions within. These results show that compact targeted lesions with sharp boundaries can be generated through intact skullcaps using histotripsy with very short pulses without using aberration correction. Such capability has the potential to greatly simplify transcranial ultrasound therapy for noninvasive transcranial applications, as current ultrasound transcranial therapy techniques all require sophisticated aberration correction.