Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
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DOI：
10.1007/s11605-019-04184-2
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发表时间：
2019-11-01
影响因子：
3.2
通讯作者：
Koerkamp, Bas Groot
中科院分区：
文献类型：
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作者：
Buettner, Stefan;ten Cate, David W. G.;Koerkamp, Bas Groot
背景肝内胆管细胞癌（ICC）多发性肿瘤常被认为是手术切除的禁忌症。我们试图定义的长期结果后，切除ICC的患者多focus.MethodsPatients谁接受了切除ICC在1990年和2017年之间，从12个主要的HPB中心确定。比较了单发病灶、多发病灶（ML）和寡转移（OM）患者的结局。OM被定义为肝外转移蔓延到一个单一的organ.Results1013例患者进行了切除ICC。在最终病理学检查中，185例患者（18.4%）患有ML，27例患者（2.7%）患有OM。单个肿瘤患者的中位生存期为43.2个月，而2个肿瘤患者的中位生存期为21.2个月; 3个或3个以上肿瘤患者的中位生存期为15.3个月（P
BackgroundMultiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci.MethodsPatients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligometastases (OM) were compared. OM were defined as extrahepatic metastases spread to a single organ.ResultsOne thousand thirteen patients underwent resection of ICC. On final pathology, 185 patients (18.4%) had ML and 27 (2.7%) had OM. Median survival of patients with a solitary tumor was 43.2 months, while the median survival of patients with 2 tumors was 21.2 months; the median survival of patients with 3 or more tumors was 15.3 months (p