Structure and function of HDL mimetics.
Structure and function of HDL mimetics.
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DOI：
10.1161/atvbaha.109.187518
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Fogelman AM
中科院分区：
文献类型：
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作者：
Navab M;Shechter I;Anantharamaiah GM;Reddy ST;Van Lenten BJ;Fogelman AM
HDL模拟物已经由许多具有不同结构的肽和蛋白质构建，所有这些肽和蛋白质都结合HDL中发现的脂质。含有肽或蛋白质的HDL模拟物已被构建为具有少至4个和多至243个氨基酸残基。一些HDL模拟物已经用脂质但没有肽或蛋白质组分构建。一些HDL模拟物促进胆固醇流出，与人载脂蛋白A-I（apoA-I）相比，一些已被证明具有显著的结合氧化脂质的能力。许多这些肽已被证明具有抗炎特性。基于在许多动物模型和早期人类临床试验中的研究，HDL模拟物似乎有希望作为诊断和治疗剂。
HDL mimetics have been constructed from a number of peptides and proteins with varying structures, all of which bind lipids found in HDL. HDL mimetics containing a peptide or protein have been constructed with as few as 4 and as many as 243 amino acid residues. Some HDL mimetics have been constructed with lipid but without a peptide or protein component. Some HDL mimetics promote cholesterol efflux, some have been shown to have a remarkable ability to bind oxidized lipids compared to human apolipoprotein A-I (apoA-I). Many of these peptides have been shown to have anti-inflammatory properties. Based on studies in a number of animal models and in early human clinical trials, HDL mimetics appear to have promise as diagnostic and therapeutic agents.