The permeability of arterial endothelium to horseradish peroxidase
The permeability of arterial endothelium to horseradish peroxidase
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动脉内皮细胞对辣根过氧化物酶的通透性
DOI：
10.1098/rspb.1970.0003
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
B. Sheppard
中科院分区：
文献类型：
--
作者：
H. Florey;B. Sheppard
当将辣根过氧化物酶蛋白静脉注射到大鼠体内时，它会迅速从血液进入动脉壁。它存在于内皮的细胞间连接中，似乎通过这一途径穿过内皮层。它也存在于小窝和小泡系统中，但尚不清楚这些是否或在多大程度上形成了跨越这一层的运输工具。它进入内皮的多泡小体和其他相对较大的小泡。在注射后的几分钟内，它会穿透弹性组织和肌肉层，并广泛分散在介质的组织空间中。
The protein horseradish peroxidase when injected intravenously into rats and mice rapidly begins to pass from the blood into the walls of arteries. It is found in the intercellular junctions of the endothelium and appears to be crossing the endothelial layer by this route. It is present also in the system of caveolae and vesicles, but it is not clear whether or to what extent these form a means of transport across this layer. It enters multi-vesicular bodies and other relatively large vesicles of the endothelium. Within a few minutes of injection it penetrates through elastic tissue and muscle layers and becomes widely dispersed in the tissue spaces of the media.