Serine proteases in schistosomes and other trematodes
Serine proteases in schistosomes and other trematodes
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DOI：
10.1016/j.ijpara.2018.01.001
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发表时间：
2018-04-01
影响因子：
4
通讯作者：
Horn, Martin
中科院分区：
文献类型：
--
作者：
Dvorak, Jan;Horn, Martin
吸虫，也称为吸虫，是一种古老的寄生生物。由于它们作为人类和兽医寄生虫的重要性，它们的蛋白质作为药物和疫苗靶标被广泛研究。其中，蛋白酶作为寄生虫生存的关键酶，被认为是抗寄生虫干预的候选分子。然而，令人惊讶的是，吸虫丝氨酸蛋白酶，与其他组的蛋白酶相比，在很大程度上被忽视。编码丝氨酸蛋白酶的基因在吸虫基因组中已被大量鉴定，但这些蛋白酶的生物学作用和生化功能知之甚少。然而，越来越多的基因组和蛋白质组学研究，以及积累的实验证据表明，这类蛋白酶在宿主-寄生虫相互作用和寄生虫生存中起着重要作用。在这里，我们详细讨论了丝氨酸蛋白酶在基因组和蛋白质水平，以及他们已知的或假设的功能。(C)2018年澳大利亚寄生虫学会。由爱思唯尔有限公司出版。保留所有权利。
Trematodes, also known as flukes, are phylogenetically ancient parasitic organisms. Due to their importance as human and veterinary parasites, their proteins have been investigated extensively as drug and vaccine targets. Among those, proteases, as crucial enzymes for parasite survival, are considered candidate molecules for anti-parasitic interventions. Surprisingly however, trematode serine proteases, in comparison with other groups of proteases, are largely neglected. Genes encoding serine proteases have been identified in trematode genomes in significant abundance, but the biological roles and biochemical functions of these proteases are poorly understood. However, increasing volumes of genomic and proteomic studies, and accumulated experimental evidence, indicate that this class of proteases plays a substantial role in host-parasite interactions and parasite survival. Here, we discuss in detail serine proteases at genomic and protein levels, and their known or hypothetical functions. (C) 2018 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.