Ancestry-related assortative mating in Latino populations
Ancestry-related assortative mating in Latino populations
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DOI：
10.1186/gb-2009-10-11-r132
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发表时间：
2009-01-01
期刊：
影响因子：
12.3
通讯作者：
Burchard, Esteban Gonzalez
中科院分区：
文献类型：
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作者：
Risch, Neil;Choudhry, Shweta;Burchard, Esteban Gonzalez
背景：虽然已记录了许多性状的配偶相关性，但之前没有研究评估混合人群中遗传血统的选型交配。结果：使用 104 个血统信息标记，我们检查了从墨西哥城和旧金山湾区招募的墨西哥配偶对以及从波多黎各和纽约市招募的波多黎各配偶对遗传血统中的配偶相关性。在墨西哥夫妇中，我们发现欧洲血统和美洲原住民血统的配偶相关性很强，但非洲血统没有相关性。在波多黎各人的配对中，我们发现非洲血统和欧洲血统的配偶相关性显着，但美洲原住民血统则不然。相关性不能归因于社会经济地位的变化或地理异质性。配偶相关性的过去证据也可见于未连锁标记之间连锁不平衡的有力证据，这在回归分析中通过一对标记的祖先等位基因频率差异进行了解释（墨西哥人为欧洲人与美洲原住民，波多黎各人为欧洲人与非洲人）。我们还观察到配偶内个体标记的纯合性过高，但这正如预期的那样提供了较弱的配偶相关性证据。预计每一代的祖先方差都会下降，但在选型交配下下降幅度较小。我们利用当前观察到的血统差异来推断前几代中配偶血统相关性更强的模式。结论：与遗传血统相关的选型交配在拉丁裔人群中持续存在至今，并影响了这些人群的基因组结构。
Background: While spouse correlations have been documented for numerous traits, no prior studies have assessed assortative mating for genetic ancestry in admixed populations.Results: Using 104 ancestry informative markers, we examined spouse correlations in genetic ancestry for Mexican spouse pairs recruited from Mexico City and the San Francisco Bay Area, and Puerto Rican spouse pairs recruited from Puerto Rico and New York City. In the Mexican pairs, we found strong spouse correlations for European and Native American ancestry, but no correlation in African ancestry. In the Puerto Rican pairs, we found significant spouse correlations for African ancestry and European ancestry but not Native American ancestry. Correlations were not attributable to variation in socioeconomic status or geographic heterogeneity. Past evidence of spouse correlation was also seen in the strong evidence of linkage disequilibrium between unlinked markers, which was accounted for in regression analysis by ancestral allele frequency difference at the pair of markers (European versus Native American for Mexicans, European versus African for Puerto Ricans). We also observed an excess of homozygosity at individual markers within the spouses, but this provided weaker evidence, as expected, of spouse correlation. Ancestry variance is predicted to decline in each generation, but less so under assortative mating. We used the current observed variances of ancestry to infer even stronger patterns of spouse ancestry correlation in previous generations.Conclusions: Assortative mating related to genetic ancestry persists in Latino populations to the current day, and has impacted on the genomic structure in these populations.