SIGNIFICANCE OF SKELETAL-MUSCLE OXIDATIVE ENZYME ENHANCEMENT WITH ENDURANCE TRAINING
SIGNIFICANCE OF SKELETAL-MUSCLE OXIDATIVE ENZYME ENHANCEMENT WITH ENDURANCE TRAINING
复制标题
DOI：
10.1111/j.1475-097x.1982.tb00001.x
复制
发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
SALTIN, B
中科院分区：
文献类型：
--
作者：
GOLLNICK, PD;SALTIN, B
提出了一种理论方法来解释耐力训练中线粒体蛋白质浓度的增加，从而导致氧化酶的增加，从而改变了亚极量运动中底物的选择，从而增加了脂肪酸的氧化，减少了糖原消耗和乳酸的产生，提高了工作能力。该模型基于酶浓度和底物浓度对酶活性的控制。在Km的基础上，给出了改变酶浓度对反应速度的影响。在特定底物浓度下的反应速度是总酶浓度的函数。在相同底物水平下，随着总酶浓度的增加，反应速度也随之增加。这将在底物水平低于酶的Km时产生最大影响。它将通过氧化途径促进脂肪酸流动，同时抑制Embden-Meyerhof途径。该模型与已知的新陈代谢变化是一致的，因为这些变化发生在耐力训练后的次极量运动中。
A theoretical method was proposed to explain how the increase in mitochondrial protein concentration, and therefore of the oxidative enzymes, that occurred with endurance training could operate to alter the choice of substrate during submaximal exercise in a manner such that the oxidation of fatty acids increases, glycogen depletion and lactate production are reduced, and work capacity is enhanced. The model was based on the control of enzyme activities both by enzyme and substrate concentrations. The effect of altering enzyme concentration on reaction velocities was presented on the basis of Km. The reaction velocity at a given substrate concentration was a function of total enzyme concentration. With an increase in total enzyme concentration there was a parallel increase in reaction velocity at the same substrate level. This would have its greatest impact at substrate levels below the Km of the enzyme. It would have an effect of enhancing fatty acid flux through the oxidative pathways while inhibiting the Embden-Meyerhof pathway. The model, as proposed, was consistent with known alterations in metabolism as they occur in man during submaximal exercise following endurance training.