Evolution of a Catabolic Pathway in Bacteria
Evolution of a Catabolic Pathway in Bacteria
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细菌分解代谢途径的进化
DOI：
10.1126/science.146.3649.1313
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发表时间：
1964
期刊：
影响因子：
56.9
通讯作者：
Estelle Lin
中科院分区：
文献类型：
--
作者：
S. Lerner;Tao Wu;Estelle Lin
核糖醇脱氢酶的遗传去阻遏突变产气荚膜杆菌，菌株1033，使其能够生长在木糖醇，底物的酶，但不是其诱导剂。从第一突变株获得了在木糖醇上具有改进的生长速率的衍生菌株。更快的生长速率是可能的生产改变核糖醇脱氢酶，证明了其活性增加木糖醇相对于核糖醇和其降低的热稳定性。
Genetic derepression of ribitol dehydrogenase in a mutant of Aerobacter aerogenes, strain 1033, enabled it to grow on xylitol, a substrate of the enzyme, but not its inducer. A derivative strain with an improved rate of growth on xylitol was obtained from the first mutant. The faster growth rate was made possible by the production of an altered ribitol dehydrogenase, as demonstrated by an increase in its activity on xylitol relative to ribitol and by its decreased heat stability.