SPECIFICITY OF COMBINATION BETWEEN RISTOCETINS AND PEPTIDES RELATED TO BACTERIAL CELL WALL MUCOPEPTIDE PRECURSORS
SPECIFICITY OF COMBINATION BETWEEN RISTOCETINS AND PEPTIDES RELATED TO BACTERIAL CELL WALL MUCOPEPTIDE PRECURSORS
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DOI：
10.1042/bj1240845
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发表时间：
1971-01-01
影响因子：
4.1
通讯作者：
PERKINS, HR
中科院分区：
文献类型：
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作者：
NIETO, M;PERKINS, HR
瑞斯托菌素B对细菌细胞壁粘蛋白前体C末端三肽序列类似物的亲和力与万古霉素相似。络合物的形成需要在C端二肽的两个氨基酸残基上有广告构型，在前面的氨基酸残基中优先有ANL-构型，多肽分子上的正电荷降低了它的亲和力。然而，瑞斯托菌素B的特异性不同于万古霉素，因为它对C末端二肽上的侧链大小的要求不同。这些差异可能解释了观察到的万古霉素和瑞斯托菌素对特定微生物的抗生素行为差异。其光学旋转色散和紫外光吸收特性与万古霉素有很大不同，但与里斯霉素A几乎相同。由里斯托霉素A制备的苷元具有抗菌活性，并能与特定的多肽结合。
The affinity of ristocetin B for analogues of theC-terminal tripeptide sequence of bacterial cell wall mucopeptide precursors resembles that of vancomycin. Complex-formation requires ad-configuration in the two amino acid residues of theC-terminal dipeptide, anl-configuration is preferred in the preceding amino acid residue and positive charges on the peptide molecule decrease its affinity. The specificity of ristocetin B, however, differs from that of vancomycin in the requirements for the size of the side chains on theC-terminal dipeptide. These differences may explain the observed differences in antibiotic behaviour of vancomycin and ristocetin with particular micro-organisms. The optical rotatory dispersion and u.v.-absorption characteristics of the ristocetins are very different from those of vancomycin but nearly identical with those of ristomycin A. Aglycones prepared from ristomycin A were antibiotically active and also combined with a specific peptide.