SLIM DISEASE - A NEW DISEASE IN UGANDA AND ITS ASSOCIATION WITH HTLV-III INFECTION
SLIM DISEASE - A NEW DISEASE IN UGANDA AND ITS ASSOCIATION WITH HTLV-III INFECTION
复制标题
DOI：
10.1016/s0140-6736(85)90122-9
复制
发表时间：
1985-01-01
期刊：
影响因子：
168.9
通讯作者：
DALGLEISH, AG
中科院分区：
文献类型：
--
作者：
SERWADDA, D;SEWANKAMBO, NK;DALGLEISH, AG
最近在乌干达农村地区发现了一种新疾病。由于主要症状是体重减轻和腹泻，因此当地人称其为瘦病。它与 HTLV-III 感染密切相关（71 名患者中有 63 名感染），并且影响女性的频率几乎与男性相同。其临床特征与邻国扎伊尔的肠病性获得性免疫缺陷综合征相似。然而，该综合征很少与卡波西肉瘤 (KS) 有关，尽管 KS 在乌干达该地区流行。苗条病主要发生在异性乱交人群中，没有明确的证据表明其他可能的传播方式，例如昆虫媒介或重复使用的注射针。首例报告病例的地点和时间表明该疾病起源于坦桑尼亚。
A new disease has recently been recognized in rural Uganda. Because the major symptoms are weight loss and diarrhoea, it is known locally as slim disease. It is strongly associated with HTLV-III infection (63 out of 71 patients) and affects females nearly as frequently as males. The clinical features are similar to those of enteropathic acquired immunodeficiency syndrome as seen in neighboring Zaire. However, the syndrome is rarely associated with Kaposi''s sarcoma (KS), althougnh KS is endemic in this area of Uganda. Slim disease occurs predominantly in the heterosexually promiscuous population and there is no clear evidence to implicate other possible means of transmission, such as by insect vectors or re-used injection needles. The site and timing of the first reported cases suggest that the disease arose in Tanzania.