Epithelial-mesenchymal transition and its implications for fibrosis.
Epithelial-mesenchymal transition and its implications for fibrosis.
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DOI：
10.1172/jci20530
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发表时间：
2003-12
期刊：
影响因子：
--
通讯作者：
R. Kalluri;E. Neilson
中科院分区：
文献类型：
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作者：
R. Kalluri;E. Neilson
上皮间质转化（EMT）是复杂组织中细胞多样化的核心机制。这个动态过程有助于组织身体计划的形成，虽然EMT在胚胎发育的背景下得到了很好的研究，但它也在成人组织器官纤维化期间成纤维细胞的发生中发挥作用。来自肾纤维化研究的新证据表明，超过三分之一的疾病相关成纤维细胞来源于损伤部位的肾小管上皮细胞。本文综述了EMT信号转导在健康和疾病过程中的最新进展，以及它如何被选择性细胞因子和生长因子减弱或逆转。
Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.