Electrophysiological correlates of anterior cingulate function in a go/no-go task: Effects of response conflict and trial type frequency
Electrophysiological correlates of anterior cingulate function in a go/no-go task: Effects of response conflict and trial type frequency
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DOI：
10.3758/cabn.3.1.17
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发表时间：
2003-03-01
影响因子：
2.9
通讯作者：
Ridderinkhof, K. Richard
中科院分区：
文献类型：
--
作者：
Nieuwenhuis, Sander;Yeung, Nick;Ridderinkhof, K. Richard
神经影像学和计算模型研究表明，前扣带皮层的反应冲突监测在认知控制中起着关键作用。例如，当一个反应必须与保持（不去）的背景下，有一个优势倾向，使一个明显的（去）反应时，反应冲突是高的。事件相关脑电位（ERP）的一个组成部分，N2，在no-go试验中比在go试验中更明显，以前被认为反映了抑制go反应的需要。然而，N2可能反而反映了不通过试验的高度反应冲突。如果是这样，当受试者在不进行事件更常见的条件下做出进行反应时，N2也应该很明显。为了验证这一假设，我们收集了高密度的ERP数据，从受试者执行去/不去的任务，其中去与不去刺激的相对频率是不同的。与我们的假设一致，N2在进行和不进行试验中都很明显，并显示出正确试验中冲突检测的ERP指标的预期属性：（1）它对低频刺激增强，无论这些刺激是否与产生或抑制反应有关，（2）它局限于前扣带皮层。这表明，以前的概念，不去N2索引反应抑制可能需要修订。相反，结果是一致的，认为去/不去任务的N2反映了冲突之间的竞争产生的执行和抑制的一个单一的反应。
Neuroimaging and computational modeling studies have led to the suggestion that response conflict monitoring by the anterior cingulate cortex plays a key role in cognitive control. For example, response conflict is high when a response must be with held (no-go) in contexts in which there is a prepotent tendency to make an overt (go) response. An event-related brain potential (ERP) component, the N2, is more pronounced on no-go than on go trials and was previously thought to reflect the need to inhibit the go response. However, the N2 may instead reflect the high degree of response conflict on no-go trials. If so, an N2 should also be apparent when subjects make a go response in conditions in which no-go events are more common. To test this hypothesis, we collected high-density ERP data from subjects performing a go/no-go task, in which the relative frequency of go versus no-go stimuli was varied. Consistent with our hypothesis, an N2 was apparent on both go and no-go trials and showed the properties expected of an ERP measure of conflict detection on correct trials: (1) It was enhanced for low-frequency stimuli, irrespective of whether these stimuli were associated with generating or suppressing a response, and (2) it was localized to the anterior cingulate cortex. This suggests that previous conceptions of the no-go N2 as indexing response inhibition may be in need of revision. Instead, the results are consistent with the view that the N2 in go/no-go tasks reflects conflict arising from competition between the execution and the inhibition of a single response.