Coregistrating magnetic source and magnetic resonance imaging for epilepsy surgery in focal cortical dysplasia.
Coregistrating magnetic source and magnetic resonance imaging for epilepsy surgery in focal cortical dysplasia.
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DOI：
10.1016/j.nicl.2018.04.034
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Rampp S
中科院分区：
文献类型：
--
作者：
Kasper BS;Rössler K;Hamer HM;Dörfler A;Blümcke I;Coras R;Roesch J;Mennecke A;Wellmer J;Sommer B;Lorber B;Lang JD;Graf W;Stefan H;Schwab S;Buchfelder M;Rampp S
局灶性皮质发育不良II型(FCD II)的癫痫手术为癫痫的缓解提供了良好的机会，但在病变检测、确定致痫区域和最佳切除策略方面仍是一个挑战。将来自脑磁图(MEG)的磁源成像结果与包括MRI后处理在内的磁共振成像(MRI)相结合，可能有助于优化这些目标。在此，我们介绍了21名成年FCDII患者的数据，他们在10年的 期间进行了调查和评估，包括磁源成像。16例行癫痫手术，即经组织病理证实的FCD II，并进行长期随访。我们根据MRI数据对包括脑磁图在内的致痫区域的结构数据进行了分析，并将这些结果与手术结果联系起来。我们队列中的FCD II具有高MEG产率和定位准确性的特点，MEG显示出对手术成功率的影响。95.2%的患者发现脑磁源定位，其距离为12.3 ± 8，1 mm。在平均随访3 年后，我们看到了80%的Engel I结果，当MEG来源被完全切除时，结果更有利(FISHERS精确检验0,033)。我们认为，在FCD II相关性癫痫患者的术前检查和切除策略中，进行脑磁图-核磁共振联合检查具有很高的价值。局灶性皮质发育不良II型(FCD II)是一种高度致痫的脑部病变。磁源成像(MSI)能够成像FCD II中与病变相关的致痫作用。MSI在95%的患者中检测到靠近病变的来源。如果切除脑磁图标记的MAP病变，癫痫的结果会更好。在FCD II手术中，将MSI整合到诊断和治疗策略中是有用的。
Epilepsy surgery for focal cortical dysplasia type II (FCD II) offers good chances for seizure freedom, but remains a challenge with respect to lesion detection, defining the epileptogenic zone and the optimal resection strategy. Integrating results from magnetic source imaging from magnetoencephalography (MEG) with magnetic resonance imaging (MRI) including MRI postprocessing may be useful for optimizing these goals. We here present data from 21 adult FCD II patients, investigated during a 10 year period and evaluated including magnetic source imaging. 16 patients had epilepsy surgery, i.e. histopathologically verified FCD II, and a long follow up. We present our analysis of epileptogenic zones including MEG in relation to structural data according to MRI data and relate these results to surgical outcomes. FCD II in our cohort was characterized by high MEG yield and localization accuracy and MEG showed impact on surgical success-rates. MEG source localizations were detected in 95.2% of patients and were as close as 12.3 ± 8,1 mm to the MRI-lesion. After a mean follow up of >3 years, we saw >80% Engel I outcomes, with more favourable outcomes when the MEG source was completely resected (Fishers exact test 0,033). We argue for a high value of conducting a combined MEG-MRI approach in the presurgical workup and the resection strategy in patients with FCD II related epilepsy. Focal cortical dysplasia Type II (FCD II) is a highly epileptogenic brain lesion. Magnetic source imaging (MSI) is able to image lesion-related epileptogenicity in FCD II. MSI detected sources close to the lesion in 95% of patients. Seizure outcomes were better if the MEG-marked MAP-lesion was resected. Integrating MSI into the diagnostic and therapeutic strategy is useful in FCD II – surgery.
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影响因子：
5.6
作者：
Boonyapisit, K;Najm, I;Lüders, H
通讯作者：
Lüders, H
影响因子：
14.5
作者：
Besson, Pierre;Andermann, Frederick;Bernasconi, Andrea
通讯作者：
Bernasconi, Andrea
影响因子：
4.8
作者：
Bonini, Francesca;McGonigal, Aileen;Bartolomei, Fabrice
通讯作者：
Bartolomei, Fabrice
DOI：
10.1016/j.nicl.2017.04.018
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bouet R;Mauguière F;Daligault S;Isnard J;Guenot M;Bertrand O;Jung J
通讯作者：
Jung J
影响因子：
5.6
作者：
Englot DJ;Nagarajan SS;Imber BS;Raygor KP;Honma SM;Mizuiri D;Mantle M;Knowlton RC;Kirsch HE;Chang EF
通讯作者：
Chang EF