Serum levels of the pro-inflammatory interleukins 6 (IL-6) and-8 (IL-8) in patients with lumbar radicular pain due to disc herniation: A 12-month prospective study
Serum levels of the pro-inflammatory interleukins 6 (IL-6) and-8 (IL-8) in patients with lumbar radicular pain due to disc herniation: A 12-month prospective study
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DOI：
10.1016/j.bbi.2015.01.008
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发表时间：
2015-05-01
影响因子：
15.1
通讯作者：
Gjerstad, Johannes
中科院分区：
文献类型：
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作者：
Pedersen, Linda Margareth;Schistad, Elina;Gjerstad, Johannes
早期的研究表明，椎间盘突出后的腰椎神经根性疼痛可能与髓核（NP）渗漏到椎管和神经孔引起的局部炎症有关。在本研究中，我们解决了两个白细胞介素，IL-6和IL-8在这种持久的腰椎神经根性疼痛的作用。所有127例患者均从挪威Ulleval的奥斯陆大学医院招募。在入选时、6周和12个月时，通过酶联免疫吸附测定（ELISA）分析IL-6和IL-8的血清浓度，并在0-10 cm视觉模拟量表（VAS）上报告疼痛强度。12个月时VAS ≥ 3的患者血清中IL-6和IL-8水平显著高于VAS ≥ 3的患者
Earlier studies indicate that lumbar radicular pain after disc herniation may be associated with a local inflammation induced by leakage of nucleus pulposus (NP) into the spinal canal and neuroforamen. In the present study we addressed the role of two interleukins, IL-6 and IL-8 in such long-lasting lumbar radicular pain. All 127 patients were recruited from Oslo University Hospital, Ulleval, Norway. At inclusion, 6 weeks and 12 months, serum concentrations of IL-6 and IL-8 were analyzed by enzyme-linked immunosorbent assay (ELISA) and pain intensity was reported on a 0-10 cm visual analog scale (VAS). Significantly higher levels of IL-6 and IL-8 in serum were found in patients with VAS >= 3 at 12 months, than in patient with VAS