Positive social behaviours are induced and retained after oxytocin manipulations mimicking endogenous concentrations in a wild mammal.
Positive social behaviours are induced and retained after oxytocin manipulations mimicking endogenous concentrations in a wild mammal.
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DOI：
10.1098/rspb.2017.0554
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发表时间：
2017-05-31
期刊：
影响因子：
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通讯作者：
Pomeroy PP
中科院分区：
文献类型：
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作者：
Robinson KJ;Twiss SD;Hazon N;Moss S;Pomeroy PP
神经肽激素催产素调节包括人类在内的多种物种的许多社交和育儿行为。我们对野生灰海豹（Halichoerus grypus）进行了操纵实验，以确定催产素是否会增加寻求接近的行为，这与野生海豹种群中的内源性催产素浓度有关。对之前从未见过面的海豹进行静脉注射0.41 µg kg−1催产素或生理盐水，并在操作后观察1小时。该剂量旨在模拟观察期间的内源性催产素浓度，是迄今为止用于操纵行为的最低剂量之一。给予催产素的海豹花了更多的时间彼此靠近，证实了催产素导致同种寻找其他人并保持接近。攻击性和调查性行为在催产素干预后也显著下降。尽管使用了最小剂量的催产素，但尽管注射后从循环中快速清除了剂量，但亲社会行为变化意外地持续了2天。这项研究验证了催产素促进个体呆在一起，展示了荷尔蒙如何在同种刺激后形成催产素释放的正反馈回路，增加保持紧密接近的动机，以及从紧密接近时收到的刺激中释放额外的催产素。
The neuropeptide hormone oxytocin modulates numerous social and parental behaviours across a wide range of species, including humans. We conducted manipulation experiments on wild grey seals (Halichoerus grypus) to determine whether oxytocin increases proximity-seeking behaviour, which has previously been correlated with endogenous oxytocin concentrations in wild seal populations. Pairs of seals that had never met previously were given intravenous injections of 0.41 µg kg−1 oxytocin or saline and were observed for 1 h post-manipulation. The dose was designed to mimic endogenous oxytocin concentrations during the observation period, and is one of the lowest doses used to manipulate behaviour to date. Seals given oxytocin spent significantly more time in close proximity to each other, confirming that oxytocin causes conspecifics to seek others out and remain close to one another. Aggressive and investigative behaviours also significantly fell after oxytocin manipulations. Despite using a minimal oxytocin dose, pro-social behavioural changes unexpectedly persisted for 2 days despite rapid dose clearance from circulation post-injection. This study verifies that oxytocin promotes individuals staying together, demonstrating how the hormone can form positive feedback loops of oxytocin release following conspecific stimuli, increased motivation to remain in close proximity and additional oxytocin release from stimuli received while in close proximity.