Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women
Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women
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健康中国女性的血清骨钙素水平与血糖和体重指数呈负相关
DOI：
10.1038/aps.2014.92
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发表时间：
2014-12-01
影响因子：
8.2
通讯作者：
Zhang, Zhen-lin
中科院分区：
文献类型：
--
作者：
Hu, Wei-wei;Ke, Yao-hua;Zhang, Zhen-lin
目的：骨钙素是骨形成的生化标志物，参与能量代谢的调节。本研究的目的是探讨血清骨钙素和糖脂代谢指标之间的可能联系在一个大样本的健康中国women.Methods：共2032名健康中国妇女，年龄在20 - 94（包括1396发现研究对象和636绝经后妇女的重复分析）。分析其血清骨钙素、钙及相关测量值。将骨钙素与其他能量代谢指标包括甘油三酯、总胆固醇、空腹血糖（FPG）、血清胰岛素、体重指数和稳态模型评估-胰岛素抵抗进行斯皮尔曼相关分析。分别对发现组和重复组的数据进行多元回归分析，以确定血清骨钙素浓度是否是糖或脂代谢指标的独立预测因子。结果：发现组的血清骨钙素与体重（r =-0.08，P = 0.002）、BMI（-0.13，P <0.001）和FPG（r =-0.13，P = 0.001）呈负相关。在重复受试者中也发现了类似的结果（体重：r =-0.19，P = 0.016; BMI：r =-0.23，P = 0.003; FPG：r =-0.28，P <0.001）。多元回归分析显示，血清骨钙素是FPG（发现和重复的β值分别为-0.07和-0.210，P <0.01）和BMI（发现和重复的β值分别为-0.127和-0.299，P <0.01）的潜在独立预测因子。结论：中国健康女性血清骨钙素与体重、BMI和FPG呈负相关。因此，骨钙素可能有助于肥胖和糖尿病。
Aim:Osteocalcin, a biochemical marker of bone formation, has been suggested to be involved in the regulation of energy metabolism. The aim of this study was to investigate the possible association between serum osteocalcin and markers of glucose and lipid metabolism in a large sample of healthy Chinese women.Methods:A total of 2032 healthy Chinese women in Shanghai, aged 20–94 (including 1396 discovery-study subjects and 636 postmenopausal women for a reduplication analysis) were recruited. Their serum osteocalcin, calcium and the relevant measurements were analyzed. A Spearman correlation analysis was performed between osteocalcin and the other markers of energy metabolism including triglyceride, total cholesterol, fasting plasma glucose (FPG), serum insulin, body mass index and homeostasis model assessment-insulin resistance. Separate multiple regression analyses were performed with data from the discovery and reduplication subjects to determine whether serum osteocalcin concentration was an independent predictor of the glucose or lipid metabolism markers.Results:For the discovery-study subjects, serum osteocalcin was found to be negatively associated with weight (r=− 0.08, P= 0.002), BMI (− 0.13, P< 0.001) and FPG (r=− 0.13, P= 0.001). Similar results were also found in the reduplication subjects (weight: r=− 0.19, P= 0.016; BMI: r=− 0.23, P= 0.003; FPG: r=− 0.28, P< 0.001). In the multiple regression analysis, serum osteocalcin was revealed as a potential independent predictor for FPG (β=− 0.07 and–0.210 for discovery and reduplication, respectively, P< 0.01) and BMI (β=− 0.127 and–0.299 for discovery and reduplication, respectively, P< 0.01).Conclusion:Serum osteocalcin is negatively associated with weight BMI and FPG in healthy Chinese women. Therefore, osteocalcin might contribute to obesity and diabetes.