Remodelling germ cells by intercellular cannibalism.
Remodelling germ cells by intercellular cannibalism.
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DOI：
10.1038/ncb3449
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发表时间：
2016-11-29
影响因子：
21.3
通讯作者：
Goldstein B
中科院分区：
文献类型：
--
作者：
Heppert JK;Goldstein B
20 世纪 80 年代初的研究报道了秀丽隐杆线虫生殖细胞前体中突出的奇怪裂片。然而，几十年来，这些叶的命运和潜在意义仍未得到探索。现在，邻近的内胚层细胞被证明可以在意想不到的“细胞间同类相食”过程中切断并消化这些叶，这可能在调节原始生殖细胞中发挥重要作用。
Work from the early 1980s reported strange lobes protruding from Caenorhabditis elegans germ cell precursors. However, the fate and potential significance of these lobes remained unexplored for decades. Now, neighbouring endodermal cells are shown to sever and digest these lobes, in an unexpected process of ‘intercellular cannibalism’, which could play an important part in regulating primordial germ cells.